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Figure 1 | Infectious Agents and Cancer

Figure 1

From: Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein

Figure 1

Representative images of HPV16 E7 oncoprotein and HIF-1α protein immunostaining of paraffin sections from oral squamous cell carcinomas. A) Tumor positive for HPV16 DNA with almost all epithelial tumor cells stained positive for E7; B) tumor negative for HPV DNA with no HPV16 E7 oncoprotein staining; C) Consecutive section of the same specimen of tumor positive for HPV16 DNA represented in "A)", stained with the anti-HIF-1α antibody: uniform location of immunoreactivity for HIF-1α and HPV16 E7 on the same tumor; D) weak expression for HIF-1α in tumor cells of tumor negative for HPV DNA (magnifications × 200; scale bars 100 μm).

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Infectious Agents and Cancer

ISSN: 1750-9378

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