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Table 5 Summary of studies analyzing the impact of ART on regression of cervical disease among HIV-infected women

From: RTehvieew impact of antiretroviral therapy on HPV andcervical intraepithelial neoplasia: current evidence and directions for future research

Author Outcome Follow-up Results Comparison and reference groups Association (95% CI) Conclusion
Minkoff et al 2001 Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL Variable follow-up HAART vs. no HAART, adjusted for CD4+ and initial Pap result OR 1.4 (1.04 - 1.82), p NR HAART has no impact on regression of SIL
Ahdieh - Grant et al 2004 2 consecutive normal Pap smears after LSIL or HSIL At least 7 years Regression rate in person years; HAART vs. no HAART 12.5% (9.9 - 15.1%) vs. 0%, OR/RR not reported Unclear (incomplete reporting)
Heard et al 1998 Pap result: SIL 12 months Regression rate (%) in women on triple-drug HAART versus those not on HAART 35% vs. 12.5%, p 0.001 HAART promotes regression of SIL
Heard et al 2002 High grade CIN or HSIL and low grade CIN or LSIL or normal. 17.7 months (median) HAART vs. no HAART, adjusted for CD4+ HR 1.93 (1.14 - 3.29), p 0.01 HAART promotes regression of SIL
Del Mistro et al 2004 Pap result: "persistence or worsening" 49% followed for >3 years HAART vs. no ART OR 0.36 (0.08-1.62), p NR HAART has no impact on regression of SIL
Moore et al 2002 High grade CIN to lower grade CIN 10 months (median) (IQR: 8 - 14) HAART naïve versus HAART - experienced OR 1.9 (0.28, 12.87), p 0.51 HAART has no impact on regression of SIL
Paramsothy et al 2009 Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL 2 - 2.7 years HAART vs. no HAART HR 1.3 (1.0 - 1.7), p >0.05 HAART has no impact on regression of SIL
Schuman et al 2003 Pap result of LSIL, HSIL 4 years (median) HAART vs. no ART OR 0.86 (0.50 - 1.47), p 0.57 HAART has no impact on regression of SIL