Table 5 Summary of studies analyzing the impact of ART on regression of cervical disease among HIV-infected women

Minkoff et al 2001

Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL

Variable follow-up

HAART vs. no HAART, adjusted for CD4+ and initial Pap result

OR 1.4 (1.04 - 1.82), p NR

HAART has no impact on regression of SIL

Ahdieh - Grant et al 2004

2 consecutive normal Pap smears after LSIL or HSIL

At least 7 years

Regression rate in person years; HAART vs. no HAART

12.5% (9.9 - 15.1%) vs. 0%, OR/RR not reported

Unclear (incomplete reporting)

Heard et al 1998

Pap result: SIL

12 months

Regression rate (%) in women on triple-drug HAART versus those not on HAART

35% vs. 12.5%, p 0.001

HAART promotes regression of SIL

Heard et al 2002

High grade CIN or HSIL and low grade CIN or LSIL or normal.

17.7 months (median)

HAART vs. no HAART, adjusted for CD4+

HR 1.93 (1.14 - 3.29), p 0.01

HAART promotes regression of SIL

Del Mistro et al 2004

Pap result: "persistence or worsening"

49% followed for >3 years

HAART vs. no ART

OR 0.36 (0.08-1.62), p NR

HAART has no impact on regression of SIL

Moore et al 2002

High grade CIN to lower grade CIN

10 months (median) (IQR: 8 - 14)

HAART naïve versus HAART - experienced

OR 1.9 (0.28, 12.87), p 0.51

HAART has no impact on regression of SIL

Paramsothy et al 2009

Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL

2 - 2.7 years

HAART vs. no HAART

HR 1.3 (1.0 - 1.7), p >0.05

HAART has no impact on regression of SIL

Schuman et al 2003

Pap result of LSIL, HSIL

4 years (median)

HAART vs. no ART

OR 0.86 (0.50 - 1.47), p 0.57

HAART has no impact on regression of SIL