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Table 2 Genes Dysregulated in EBV-positive AGS Cells

From: Epstein-Barr virus-specific methylation of human genes in gastric cancer cells

Gene Name Gene Symbol Fold Change*
Downregulated Genes
basic leucine-zipper transcription factor, ATF-like BATF -38
cyclooxygenase-2 COX2 -35
bone morphogenic protein-4 BMP4 -32
intercellular adhesion molecule-1 ICAM1 -22
trefoil factor-1 TFF1 -21
inhibitor of DNA binding-2 ID2 -14
heat shock protein-70 HSP70 -10
cyclin-dependent kinase-2 CDK2 -9
cyclin-D1 CCND1 -9
hypoxia inducible factor-1A HIF1A -9
breast cancer-1 BRCA1 -7
nucleostemin NU -7
cyclin-dependent kinase inhibitor-2A CDKN2A/p16 -6
inhibitor of DNA binding-4 ID4 -6
engrailed-1 EN1 -5
ATP-binding cassette, sub-family B, member 1 ABCB1 -3
MDM2 p53 binding protein MDM2 -3
Upregulated Genes
insulin-like growth factor binding protein-3 IGFBP3 +40
tumor necrosis factor receptor-associated factor-1 TRAF1 +20
transmembrane prostate androgen-induced protein TMEPAI +10
tumor necrosis factor, superfamily member-10 TNFSF10 +8
B cell lymphoma-2-like-1 BCL2L1 +7
baculoviral IAP repeat containing-3 BIRC3 +5
hexokinase-1 HK1 +5
FOS-like antigen-1 FOSL1 +3
  1. *Listed are genes dysregulated by >2-fold using rtPCR