Table 2 Association between HLA alleles and KSHV DNA detection in saliva and peripheral blood among children in the Uganda Sickle Cell Anemia KSHV Study, 2001-2002
Allele | # KSHV DNA positive/#KSHV DNA negative | OR (95% CI) | P-value | # KSHV DNA positive/#KSHV DNA negative | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|
Saliva A priori-motivated analyses | Peripheral blood | |||||
HLA-A*30 | ||||||
Absent | 20/121 | 1 | 26/130 | 1 | ||
At least 1 *3001 | 5/29 | 1.1 (0.5-4.3) | 0.5 | 3/23 | 0.6 (0.2-2.2) | 0.8 |
At least *3002 | 9/24 | 1.8 (0.8-4.1) | 0.2 | 7/34 | 1.1 (0.5-2.7) | 0.9 |
HLA-A*68 | ||||||
Absent | 30/139 | 1 | 31/153 | 1 | ||
At least1*6801 | 0/6 | 0.0 | 0.6 | 1/5 | 1.0 (0.1-9.2) | 1.0 |
At least1*6802 | 4/29 | 0.5 (0.1-1.8) | 0.3 | 4/29 | 0.7 (0.2-2.3) | 0.6 |
HLA-DRB1*04 | ||||||
Absent | 32/173 | 1 | 34/187 | 1 | ||
At least 1*0405 | 1/3 | 1.8 (0.1-5.2) | 0.5 | 2/2 | 5.5 (0.7-40.3) | 0.1 |
Explorative analyses | ||||||
HLA-B*08 | ||||||
Absent | 31/160 | 1 | 29/176 | 1 | ||
At least 1*0801 | 3/14 | 1.1 (0.3-4.1) | 0.9 | 7/11 | 3.9 (1.4-10.8) | 0.01 |
HLA-B*44 | ||||||
Absent | 30/165 | 1 | 33/176 | 1 | ||
At least 1*4403 | 1/6 | 1.1 (0.1- 9.9) | 0.9 | 2/6 | 1.9 (0.3-9.1) | 0.2 |
At least 1*4415 | 3/3 | 5.5 (1.1-28.6) | 0.02 | 1/5 | 1.1 (0.1-9.2) | 0.9 |