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Table 1 Weighted* HLA allele group prevalence among children and mothers in the Uganda Sickle Cell Anemia KSHV Study, 2001-2002

From: HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study

  Children Women  
HLA group Number typed† Percent positive for allele group (number positive) Number typed† Percent positive for allele group (number positive) p-value
HLA-A 223   226   
   *01   5.1 (22)   3.5 (22)  
   *02   19.5 (82)   20.0 (78)  
   *03   5.2 (23)   4.6 (28)  
   *23   10.2 (42)   8.8 (38)  
   *29   5.0 (32)   7.3 (37)  
   *30   12.0 (75)   13.7 (82)  
   *36   5.4 (13)   5.2 (13)  
   *66   5.0 (26)   8.0 (36)  
   *68   11.5 (39)   10.6 (43)  
   *74   10.7 (38)   6.2 (31)  
      0.94
HLA-B 225   225   
   *07   4.9 (18)   6.2 (18)  
   *08   3.4 (18)   3.1 (15)  
   *15   10.5 (59)   9.0 (65)  
   *42   6.8 (35)   8.9 (40)  
   *44   3.9 (14)   3.1 (16)  
   *45   8.0 (32)   11.9 (41)  
   *49   1.5 (13)   5.3 (16)  
   *53   11.6 (40)   8.7 (36)  
   *57   5.9 (21)   2.1 (22)  
   *58   16.6 (59)   16.8 (73)  
   *82   6.1 (6)   0.1 (2)  
      0.98
HLA-DRB1 223   227   
   *01   10.5 (48)   8.0 (37)  
   *03   9.4 (56)   10.1 (59)  
   *04   1.0 (4)   1.7 (4)  
   *07   6.5 (31)   5.8 (37)  
   *08   5.0 (20)   5.6 (20)  
   *11   28.2 (113)   28.8 (116)  
   *12   3.7 (11)   6.1 (17)  
   *13   11.7 (68)   12.3 (59)  
   *15   15.9 (61)   14.4 (70)  
      0.95
  1. * For both children and their mothers prevalence for HLA-A, -B, -DRB1 allele groups was weighted according to KSHV serostatus of the children (the selection criteria for inclusion in the study) using the formula: weighted prevalence (α) of HLA allele group X in the children (or mothers) = (Prevalence of X in KSHV negative children (or mothers) × proportion of KSHV negative children) + (Prevalence of X in KSHV positive children (or mothers) × Prevalence of KSHV positive children). See methods in text for details.
  2. † Total is less than 233 because fewer subjects were successfully typed for HLA-A, -B and -DRB1
  3. ‡ P-value for heterogeneity comparing HLA-A, -B and -DRB1 allele group distribution between mothers and children