Table 1 The point nucleotide mutations and amino acid changes observed in the BARF1 gene sequence from 56 NPC patients, 15 other EBV-related disorders, and 5 healthy individuals (one isolate might show more than one mutation).
Nucleotide no. | Nucleotide change | AA No. | AA change | NPC (n = 56) | Non-NPC (n = 15) | Healthy (n = 5) |
|---|---|---|---|---|---|---|
165540 | T → A | 12 | S → T | 1 | 0 | 0 |
165575 | C → T | 24 | no change | 1 | 0 | 0 |
165589 | T → C | 29 | V → A | 44 | 5 | 2 |
165681 | A → G | 59 | no change | 1 | 0 | 0 |
165717 | T → G | 72 | W → G | 8 | 0 | 0 |
165768 | T → C | 88 | no change | 37 | 3 | 2 |
165779 | C → T | 92 | no change | 28 | 1 | 2 |
165797 | T → C | 98 | no change | 36 | 1 | 2 |
165886 | C → T | 128 | S → F | 1 | 0 | 0 |
165892 | A → G | 130 | H → R | 44 | 2 | 2 |
165944 | C → T | 147 | no change | 37 | 5 | 2 |