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Volume 4 Supplement 2

Proceedings of the 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research

Exploring Kaposi's sarcoma-associated herpesvirus latent genes' role in viral lymphomagenesis using transgenic mice

Infectious Agents and Cancer volume 4, Article number: P39 (2009) Cite this article

Kaposi's sarcoma-associated herpesvirus (KSHV) is a human lymphotropic gammaherpesvirus and associated with Kaposi sarcoma as well as two B cell lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease. We reported that the KSHV latency-associated nuclear antigen (LANA) transgenic mice developed splenic follicular hyperplasia and showed increased germinal center formation. Here we report that the KSHV LANA-induced B cell activation is CD19 dependent and LANA restores the marginal zone defect in CD19-/- mice. To test KSHV latent genes' role in viral lymphomagenesis, we generated mice expressing all KSHV latency-associated genes. All of the transgenic mice induced mature B cell activation. Further characterization of the mice expressing all KSHV latency-associated genes is currently underway.

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  1. Department of Microbiology and Immunology and Lineberger comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    S-H Sin, FD Fakhari & DP Dittmer

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  1. S-H Sin
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  2. FD Fakhari
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  3. DP Dittmer
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sin, SH., Fakhari, F. & Dittmer, D. Exploring Kaposi's sarcoma-associated herpesvirus latent genes' role in viral lymphomagenesis using transgenic mice. Infect Agents Cancer 4 (Suppl 2), P39 (2009). https://doi.org/10.1186/1750-9378-4-S2-P39

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  • DOI: https://doi.org/10.1186/1750-9378-4-S2-P39

Keywords

  • Sarcoma
  • Transgenic Mouse
  • Cell Activation
  • Latent Gene
  • Germinal Center

Infectious Agents and Cancer

ISSN: 1750-9378

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