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Open Access

Exploring Kaposi's sarcoma-associated herpesvirus latent genes' role in viral lymphomagenesis using transgenic mice

  • S-H Sin1,
  • FD Fakhari1 and
  • DP Dittmer1
Infectious Agents and Cancer20094(Suppl 2):P39

Published: 17 June 2009


SarcomaTransgenic MouseCell ActivationLatent GeneGerminal Center

Kaposi's sarcoma-associated herpesvirus (KSHV) is a human lymphotropic gammaherpesvirus and associated with Kaposi sarcoma as well as two B cell lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease. We reported that the KSHV latency-associated nuclear antigen (LANA) transgenic mice developed splenic follicular hyperplasia and showed increased germinal center formation. Here we report that the KSHV LANA-induced B cell activation is CD19 dependent and LANA restores the marginal zone defect in CD19-/- mice. To test KSHV latent genes' role in viral lymphomagenesis, we generated mice expressing all KSHV latency-associated genes. All of the transgenic mice induced mature B cell activation. Further characterization of the mice expressing all KSHV latency-associated genes is currently underway.

Authors’ Affiliations

Department of Microbiology and Immunology and Lineberger comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, USA


© Sin et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.