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  • Poster presentation
  • Open Access

Exploring Kaposi's sarcoma-associated herpesvirus latent genes' role in viral lymphomagenesis using transgenic mice

  • 1,
  • 1 and
  • 1
Infectious Agents and Cancer20094 (Suppl 2) :P39

https://doi.org/10.1186/1750-9378-4-S2-P39

  • Published:

Keywords

  • Sarcoma
  • Transgenic Mouse
  • Cell Activation
  • Latent Gene
  • Germinal Center

Kaposi's sarcoma-associated herpesvirus (KSHV) is a human lymphotropic gammaherpesvirus and associated with Kaposi sarcoma as well as two B cell lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease. We reported that the KSHV latency-associated nuclear antigen (LANA) transgenic mice developed splenic follicular hyperplasia and showed increased germinal center formation. Here we report that the KSHV LANA-induced B cell activation is CD19 dependent and LANA restores the marginal zone defect in CD19-/- mice. To test KSHV latent genes' role in viral lymphomagenesis, we generated mice expressing all KSHV latency-associated genes. All of the transgenic mice induced mature B cell activation. Further characterization of the mice expressing all KSHV latency-associated genes is currently underway.

Authors’ Affiliations

(1)
Department of Microbiology and Immunology and Lineberger comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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