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Infectious Agents and Cancer

Open Access

Burkitt lymphoma in Brazil is characterized by geographically distinct clinico-pathological features and lack of p53 mutations

  • E Queiroga1, 2,
  • G Gualco1,
  • L Weiss3,
  • D Dittmer4,
  • I Araujo5,
  • C Klumb6,
  • W HarringtonJr7,
  • E Os and
  • C Bacchi1, 2
Infectious Agents and Cancer20094(Suppl 2):P22

Published: 17 June 2009


Geographic RegionEpstein Barr VirusClinical VariantSporadic CaseBurkitt Lymphoma

Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma with a consistent MYC translocation. Epstein Barr virus (EBV) has been associated with BL at different frequencies depending on the clinical variant and geographic regions. This is a large-scale study of BL in Brazil, including 234 patients from five geographic regions that are widely disparate socioeonomically, including both the pediatric (61.1%) and adult (37.6%) populations. EBV was present in 52.5 percent of all BL cases, varying from 28.6 percent in the South to 76.4 percent in the North. Most of the cases were EBV type A. The frequency was higher in the pediatric group and EBV association within this age range predominated in all regions except the South. p53 protein expression was observed in 16.2 percent and only rare cases showed p63 expression. BL in Brazil is regionally distinct, has a low incidence of p53 over expression and a higher than expected association with EBV in sporadic cases.

Authors’ Affiliations

Consultoria Patologia, Botucatu, Brazil
University of São Paulo Medical School, Brazil
Division of Pathology at the City of Hope National Medical Center, Duarte, USA
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
Prof. Edgard Santos University Hospital, Salvador, Brazil
Instituto Nacional do Cancer, Rio de Janeiro, Brazil
University of Miami Miller School of Medicine and Sylvester Cancer Center, Fogarty International Center (AIDS and Tuberculosis Program), Miami, USA


© Queiroga et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.