Table 2 Potential uses of ACSR banked specimens
From: The AIDS and Cancer Specimen Resource: Role in HIV/AIDS scientific discovery
Type | Use | |
|---|---|---|
Autopsies (multi-site) frozen & fixed | DNA and protein studies within individuals; involved vs. uninvolved tissues | |
| Â | Tissue array analyses | Comparison of antigen expression between many patient tumors |
| Â | Â | Diseased tissue specific cytokine, virus, antigen expression |
Frozen lymphoma, KS and tumor tissues | DNA, RNA, and protein array studies; viral discovery/strain variation studies | |
Non Hodgkin's lymphoma (AIDS & non-AIDS) epidemiology study (serum & fixed tissue) | Serologic studies on cases vs. controls for cytokine, viral antigen, serum proteins. Coupled with epidemiologic data in collaboration with Dr. Elizabeth Holly test disease associations, risk factors, transmission risk factors, resistance factors, lymphoma tissue, DNA/protein correlation with serum factors/disease associations. | |
AIDS Malignancy Consortium clinical trial specimens | Longitudinal, trial associated specimens for analyses of disease specific markers in collaboration with AMC | |
Serum specimens from cross-sectional survey in Thailand | Studies on low KS prevalence untreated HIV & serum cohort Infected vs. uninfected age & sex matched specimen comparisons | |
| Â | Studies on HIV, non-US viral isolates. Repeat blood draws from HIV+ individuals available for rate of variation studies. | |
Ano-genital specimens from men and women HIV+/HIV- | Study role of HIV strains in early stages of ano-genital carcinogenesis | |
Plastic embedded tissue suitable for transmission electron microscopy | Evaluation of virus identity, morphogenesis, and cytopathology in various disease states | |