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Table 2 Risk of developing selected cancers in relation to anti-HPV-16 IgG OD levels

From: The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population

Cancer site or type

HPV-16 OD status

Comparison group (N)

Cases (N)

OR1(95% CI)

Adj. OR2(95% CI)

Adj. OR3(95% CI)

Cervix (women only)

      
 

Low (Negative)<0.45

512

201

1

1

1

 

Medium 0.45–0.767

411

273

1.71

1.50(1.18–1.90)

1.64(1.30–2.08)

 

High >0.767

459

472

2.63

2.38 (1.91–2.97)

2.50(2.01–3.11)

 

P-trend

  

<0.0001

<0.0001*

<0.0001 †

Anogenital organs (men and women)

      
 

Low <0.45

798

15

1

1

1

 

Medium or high > = 0.45

1257

65

2.69

2.30(1.28–4.11)

2.49(1.40–4.43)

 

P=

  

0.0007

0.005**

0.002 ††

Oral cavity and pharynx (men and women)

      
 

Low (Negative)<0.45

798

33

1

1

1

 

Medium 0.45–0.767

625

32

1.18

1.13(0.66–1.91)

1.09(0.64–1.83)

 

High >0.767

632

37

1.65

1.49(0.89–2.51)

1.47(0.88–2.47)

 

P-trend

  

0.05

0.13***

0.13 †††

Oesophagus (men and women)

      
 

Low (Negative)<0.45

798

112

1

1

1

 

Medium 0.45–0.767

625

123

1.33

1.25(0.92–1.69)

1.26(0.94–1.70)

 

High >0.767

632

134

1.65

1.53(1.14–2.07)

1.59(1.19–2.13)

 

P-trend

  

0.0006

0.0005***

0.002 ††††

Prostate (men only)

      
 

Low (Negative)<0.45

286

65

1

1

1

 

Medium 0.45–0.767

214

81

1.39

1.33(0.87–2.04)

1.39(0.93–2.09)

 

High >0.767

173

59

1.33

1.22(0.77–1.93)

1.33(0.86–2.07)

 

P-trend

   

0.35****

0.18 †††††

  1. Notes: Adjustment factors
  2. OR1: Age and sex (where appropriate)
  3. OR2:
  4. * Age group, education, parity, number of sexual partners, birthplace, current residence and smoking
  5. ** Age group, education, parity and sex (see methods), number of sexual partners, birthplace, current residence and smoking.
  6. *** Age group, sex, education, birthplace, current residence, alcohol usage and smoking.
  7. **** Age group, education, birthplace, current residence and number of sexual partners.
  8. OR3:
  9. † Education, parity, number of sexual partners and smoking
  10. †† Sex, smoking, parity
  11. ††† Age group, sex, smoking, current residence, education
  12. †††† Age group, sex, smoking, education
  13. ††††† Age group, sex, smoking, education