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Table 1 HPV genotyping by DNA Sequencing v. Digene HC2 Test

From: Routine human papillomavirus genotyping by DNA sequencing in community hospital laboratories

PCR/DNA Sequencing

Test Results by Digene HC2

Type Positive Cases

Prevalence (%)

High-risk+

Negative

16

29

(27.2)

11

18

56

9

(8.5)

9

0

31

7

(6.5)

5

2

6

6

(5.6)

2

4

18

6

(5.6)

6

0

54

6

(5.6)

3

3

58

6

(5.6)

5

1

66

6

(5.6)

6

0

59

4

(3.7)

4

0

45

3

(2.8)

2

1

83

3

(2.8)

2

1

32

2

(1.9)

0

2

35

2

(1.9)

1

1

39

2

(1.9)

2

0

40

2

(1.9)

0

2

52

2

(1.9)

1

1

33

1

(0.9)

1

0

53

1

(0.9)

1

0

62

1

(0.9)

1

0

68

1

(0.9)

1

0

70

1

(0.9)

1

0

72

1

(0.9)

0

1

73

1

(0.9)

0

1

M16

1

(0.9)

1

0

M 16, 18

1

(0.9)

1

0

M others

3

(2.9)

1

2

Total

107

(100)

67

40

   

HC2 HPV detection rate = 67/107 = 62.6%

Samples

513

   

%HPV+ 20.9

    
  1. M16 = mixed infection with HPV 16 identified by type-specific sequencing primer.
  2. M 16, 18 = mixed infection with HPV 16 and HPV 18 identified by type-specific sequencing primers.
  3. M others = mixed infections by HPV types which cannot be sequenced with type-specific primers for HPV 6, 11, 16 or 18.
  4. Digene High-risk + includes those cases reported as positive for both High-risk and Low-risk HPV types.
  5. The underlined HPV genotypes are included in the "High-risk" Digene HC2 cocktail probe.
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Infectious Agents and Cancer

ISSN: 1750-9378

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