|
Risk factor
| |
Virus
|
|---|
| | |
HSV-1
|
HSV-2
|
VZV
|
EBV-EBNA
|
CMV
|
HHV-6
|
|---|
|
Age
|
<20
|
1.55 (0.11)
|
-0.19 (0.20)
|
1.06 (0.12)
|
1.52 (0.15)
|
1.79 (0.21)
|
0.64 (0.15)
|
| |
20–39
|
1.61 (0.04)
|
0.25 (0.08)
|
1.06 (0.05)
|
1.44 (0.07)
|
2.19 (0.12)
|
0.70 (0.06)
|
| |
40–59
|
1.61 (0.04)
|
0.36 (0.07)
|
1.07 (0.05)
|
1.40 (0.07)
|
2.26 (0.07)
|
0.74 (0.06)
|
| |
60+
|
1.60 (0.05)
|
0.48 (0.08)
|
1.11 (0.06)
|
1.47 (0.07)
|
2.41 (0.09)
|
0.66 (0.05)
|
|
p-value
| |
0.92
|
0.003
|
0.41
|
0.77
|
0.006
|
0.52
|
|
Sex
|
Males
|
1.59 (0.05)
|
0.05 (0.08)
|
1.03 (0.06)
|
1.43 (0.07)
|
1.98 (0.09)
|
0.59 (0.06)
|
| |
Females
|
1.60 (0.05)
|
0.40 (0.08)
|
1.11 (0.06)
|
1.48 (0.07)
|
2.34 (0.10)
|
0.78 (0.06)
|
|
p-value
| |
0.91
|
<0.0001
|
0.09
|
0.44
|
<0.0001
|
0.0002
|
|
Smoking
|
Never
|
1.60 (0.04)
|
0.21 (0.08)
|
1.03 (0.05)
|
1.45 (0.07)
|
2.16 (0.09)
|
0.67 (0.06)
|
| |
Ever
|
1.59 (0.05)
|
0.24 (0.09)
|
1.11 (0.06)
|
1.46 (0.08)
|
2.17 (0.10)
|
0.70 (0.06)
|
|
p-value
| |
0.91
|
0.56
|
0.07
|
0.96
|
0.94
|
0.34
|
|
Education
|
< Grade 3
|
1.59 (0.05)
|
0.30 (0.09)
|
1.10 (0.06)
|
1.41 (0.08)
|
2.18 (0.10)
|
0.74 (0.07)
|
| |
Grade 3–7
|
1.64 (0.05)
|
0.24 (0.08)
|
1.09 (0.05)
|
1.47 (0.07)
|
2.13 (0.09)
|
0.69 (0.06)
|
| |
Grade 8+
|
1.55 (0.05)
|
0.14 (0.09)
|
1.04 (0.06)
|
1.49 (0.08)
|
2.18 (0.10)
|
0.64 (0.07)
|
|
p-value
| |
0.53
|
0.09
|
0.26
|
0.18
|
0.99
|
0.14
|
|
Area of birth
|
Urban
|
1.61 (0.05)
|
0.28 (0.09)
|
1.10 (0.06)
|
1.46 (0.07)
|
2.14 (0.10)
|
0.70 (0.06)
|
| |
Rural
|
1.57 (0.04)
|
0.18 (0.08)
|
1.05 (0.05)
|
1.45 (0.07)
|
2.19 (0.09)
|
0.67 (0.07)
|
|
p-value
| |
0.29
|
0.13
|
0.16
|
0.67
|
0.48
|
0.45
|
|
Area living
|
Urban
|
1.59 (0.04)
|
0.19 (0.07)
|
1.08 (0.05)
|
1.45 (0.07)
|
2.17 (0.09)
|
0.71 (0.06)
|
| |
Rural
|
1.59 (0.05)
|
0.27 (0.09)
|
1.07 (0.06)
|
1.46 (0.08)
|
2.15 (0.11)
|
0.67 (0.06)
|
|
p-value
| |
0.99
|
0.35
|
0.83
|
0.76
|
0.85
|
0.53
|
|
HIV
|
+ve
|
1.53 (0.06)
|
0.27 (0.11)
|
1.12 (0.07)
|
1.43 (0.09)
|
2.22 (0.12)
|
0.71 (0.08)
|
| |
-ve
|
1.66 (0.04)
|
0.18 (0.07)
|
1.02 (0.05)
|
1.48 (0.06)
|
2.11 (0.08)
|
0.67 (0.05)
|
|
p-value
| |
0.03
|
0.35
|
0.10
|
0.52
|
0.34
|
0.66
|
|
No. of
|
0–2
|
1.60 (0.05)
|
0.12 (0.08)
|
1.02 (0.06)
|
1.47 (0.07)
|
2.12 (0.09)
|
0.64 (0.06)
|
|
sexual
|
3–5
|
1.58 (0.05)
|
0.25 (0.08)
|
1.05 (0.06)
|
1.41 (0.07)
|
2.18 (0.09)
|
0.75 (0.06)
|
|
partners
|
6+
|
1.60 (0.05)
|
0.31 (0.09)
|
1.15 (0.06)
|
1.49 (0.08)
|
2.19 (0.11)
|
0.67 (0.07)
|
|
p-value
| |
0.96
|
0.01
|
0.03
|
0.96
|
0.34
|
0.26
|
|
Marital
|
Single
|
1.58 (0.04)
|
0.06 (0.08)
|
1.04 (0.05)
|
1.45 (0.07)
|
2.03 (0.09)
|
0.65 (0.06)
|
|
status
|
Married
|
1.62 (0.05)
|
0.22 (0.08)
|
1.11 (0.05)
|
1.43 (0.07)
|
2.16 (0.09)
|
0.67 (0.06)
|
| |
Widowed
|
1.59 (0.06)
|
0.20 (0.11)
|
1.04 (0.07)
|
1.41 (0.09)
|
2.17 (0.12)
|
0.66 (0.08)
|
| |
Separated
|
1.58 (0.07)
|
0.42 (0.12)
|
1.10 (0.08)
|
1.54 (0.10)
|
2.29 (0.14)
|
0.77 (0.09)
|
|
p-value
| |
0.64
|
0.005
|
0.45
|
0.52
|
0.26
|
0.34
|
- Multivariate analysis of variance excluding patients with multiple myeloma and adjusted for all factors above plus disease group, plate and day of assay. P-values are for trend tests where appropriate and otherwise for heterogeneity.
