Antibodies against six human herpesviruses in relation to seven cancers in black South Africans: A case control study

de González, A Berrington; Urban, MI; Sitas, F; Blackburn, N; Hale, M; Patel, M; Ruff, P; Sur, R; Newton, R; Beral, V

doi:10.1186/1750-9378-1-2

Table 3 Mean log antibody measure (and standard error) for human herpesviruses 1–6 according to age at diagnosis, sex and other socio-demographic factors.

From: Antibodies against six human herpesviruses in relation to seven cancers in black South Africans: A case control study

Risk factor		Virus
		HSV-1	HSV-2	VZV	EBV-EBNA	CMV	HHV-6
Age	<20	1.55 (0.11)	-0.19 (0.20)	1.06 (0.12)	1.52 (0.15)	1.79 (0.21)	0.64 (0.15)
	20–39	1.61 (0.04)	0.25 (0.08)	1.06 (0.05)	1.44 (0.07)	2.19 (0.12)	0.70 (0.06)
	40–59	1.61 (0.04)	0.36 (0.07)	1.07 (0.05)	1.40 (0.07)	2.26 (0.07)	0.74 (0.06)
	60+	1.60 (0.05)	0.48 (0.08)	1.11 (0.06)	1.47 (0.07)	2.41 (0.09)	0.66 (0.05)
*p-value*		*0.92*	*0.003*	*0.41*	*0.77*	*0.006*	*0.52*
Sex	Males	1.59 (0.05)	0.05 (0.08)	1.03 (0.06)	1.43 (0.07)	1.98 (0.09)	0.59 (0.06)
	Females	1.60 (0.05)	0.40 (0.08)	1.11 (0.06)	1.48 (0.07)	2.34 (0.10)	0.78 (0.06)
*p-value*		*0.91*	*<0.0001*	*0.09*	*0.44*	*<0.0001*	*0.0002*
Smoking	Never	1.60 (0.04)	0.21 (0.08)	1.03 (0.05)	1.45 (0.07)	2.16 (0.09)	0.67 (0.06)
	Ever	1.59 (0.05)	0.24 (0.09)	1.11 (0.06)	1.46 (0.08)	2.17 (0.10)	0.70 (0.06)
*p-value*		*0.91*	*0.56*	*0.07*	*0.96*	*0.94*	*0.34*
Education	< Grade 3	1.59 (0.05)	0.30 (0.09)	1.10 (0.06)	1.41 (0.08)	2.18 (0.10)	0.74 (0.07)
	Grade 3–7	1.64 (0.05)	0.24 (0.08)	1.09 (0.05)	1.47 (0.07)	2.13 (0.09)	0.69 (0.06)
	Grade 8+	1.55 (0.05)	0.14 (0.09)	1.04 (0.06)	1.49 (0.08)	2.18 (0.10)	0.64 (0.07)
*p-value*		*0.53*	*0.09*	*0.26*	*0.18*	*0.99*	*0.14*
Area of birth	Urban	1.61 (0.05)	0.28 (0.09)	1.10 (0.06)	1.46 (0.07)	2.14 (0.10)	0.70 (0.06)
	Rural	1.57 (0.04)	0.18 (0.08)	1.05 (0.05)	1.45 (0.07)	2.19 (0.09)	0.67 (0.07)
*p-value*		*0.29*	*0.13*	*0.16*	*0.67*	*0.48*	*0.45*
Area living	Urban	1.59 (0.04)	0.19 (0.07)	1.08 (0.05)	1.45 (0.07)	2.17 (0.09)	0.71 (0.06)
	Rural	1.59 (0.05)	0.27 (0.09)	1.07 (0.06)	1.46 (0.08)	2.15 (0.11)	0.67 (0.06)
*p-value*		*0.99*	*0.35*	*0.83*	*0.76*	*0.85*	*0.53*
HIV	+ve	1.53 (0.06)	0.27 (0.11)	1.12 (0.07)	1.43 (0.09)	2.22 (0.12)	0.71 (0.08)
	-ve	1.66 (0.04)	0.18 (0.07)	1.02 (0.05)	1.48 (0.06)	2.11 (0.08)	0.67 (0.05)
*p-value*		*0.03*	*0.35*	*0.10*	*0.52*	*0.34*	*0.66*
No. of	0–2	1.60 (0.05)	0.12 (0.08)	1.02 (0.06)	1.47 (0.07)	2.12 (0.09)	0.64 (0.06)
sexual	3–5	1.58 (0.05)	0.25 (0.08)	1.05 (0.06)	1.41 (0.07)	2.18 (0.09)	0.75 (0.06)
partners	6+	1.60 (0.05)	0.31 (0.09)	1.15 (0.06)	1.49 (0.08)	2.19 (0.11)	0.67 (0.07)
*p-value*		*0.96*	*0.01*	*0.03*	*0.96*	*0.34*	*0.26*
Marital	Single	1.58 (0.04)	0.06 (0.08)	1.04 (0.05)	1.45 (0.07)	2.03 (0.09)	0.65 (0.06)
status	Married	1.62 (0.05)	0.22 (0.08)	1.11 (0.05)	1.43 (0.07)	2.16 (0.09)	0.67 (0.06)
	Widowed	1.59 (0.06)	0.20 (0.11)	1.04 (0.07)	1.41 (0.09)	2.17 (0.12)	0.66 (0.08)
	Separated	1.58 (0.07)	0.42 (0.12)	1.10 (0.08)	1.54 (0.10)	2.29 (0.14)	0.77 (0.09)
*p-value*		*0.64*	*0.005*	*0.45*	*0.52*	*0.26*	*0.34*

Multivariate analysis of variance excluding patients with multiple myeloma and adjusted for all factors above plus disease group, plate and day of assay. P-values are for trend tests where appropriate and otherwise for heterogeneity.

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ISSN: 1750-9378

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