African cancers

Section edited by: Prof Twalib Ngoma  and Prof Henry R Wabinga.

This section will allow African oncologists to describe the current oncology issues along with their findings/achievements for those 'tropical' cancers, such as EBV-related Burkitt lymphoma and schistosomiasis-related bladder cancer, which are considered rare in the rest of the world.

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  1. Research Article

    Prevalence and risk factors associated with sexually transmitted infections (STIs) among women of reproductive age in Swaziland

    Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15–49 years. Epidemiological data on STIs among women of...

    Themba G. Ginindza, Cristina D. Stefan, Joyce M. Tsoka-Gwegweni, Xolisile Dlamini, Pauline E. Jolly, Elisabete Weiderpass, Nathalie Broutet and Benn Sartorius

    Infectious Agents and Cancer 2017 12:29

    Published on: 25 May 2017

  2. Research Article

    Differences in age-specific HPV prevalence between self-collected and health personnel collected specimen in a cross-sectional study in Ghana

    HPV infections are ubiquitous and particularly common among sexually active young women. However, there are regional and national variations in age-specific HPV prevalence, which have implications for cervical...

    Adolf K. Awua, Richard M. K. Adanu, Edwin K. Wiredu, Edwin A. Afari and Alberto Severini

    Infectious Agents and Cancer 2017 12:26

    Published on: 18 May 2017

  3. Research Article

    Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma

    Aflatoxin B1 (AFB1) contamination of food is very high in most sub-Saharan African countries. AFB1 is known to cause hepatocellular carcinoma (HCC) by inducing mutation in the tumour suppressor gene TP53. The num...

    Patrick W. Narkwa, David J. Blackbourn and Mohamed Mutocheluh

    Infectious Agents and Cancer 2017 12:17

    Published on: 20 March 2017

  4. Review

    An update on the management of breast cancer in Africa

    There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the burden of breast canc...

    V. Vanderpuye, S. Grover, N. Hammad, PoojaPrabhakar, H. Simonds, F. Olopade and D. C. Stefan

    Infectious Agents and Cancer 2017 12:13

    Published on: 14 February 2017

  5. Research Article

    Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria

    Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal sampl...

    Fatima Modibbo, K. C. Iregbu, James Okuma, Annemiek Leeman, Annemieke Kasius, Maurits de Koning, Wim Quint and Clement Adebamowo

    Infectious Agents and Cancer 2017 12:11

    Published on: 6 February 2017

  6. Position Statement

    African Organization for Research and Training in Cancer: position and vision for cancer research on the African Continent

    The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including informa...

    J. Olufemi Ogunbiyi, D. Cristina Stefan and Timothy R. Rebbeck

    Infectious Agents and Cancer 2016 11:63

    Published on: 6 December 2016

  7. Research Article

    Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

    Little is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HP...

    R. Ghedira, W. Mahfoudh, S. Hadhri, S. Gabbouj, I. Bouanene, H. Khairi, A. Chaieb, R. Khelifa, N. Bouaouina, S. Remadi, A. A. Elmi, D. Bansal, A. A. Sultan, R. Faleh, A. Zakhama, L. Chouchane…

    Infectious Agents and Cancer 2016 11:61

    Published on: 1 December 2016

  8. Research Article

    Changing Patterns of lung, liver, and head and neck non-AIDS-defining cancers relative to HIV status in Tanzania between 2002-2014

    Tanzania, like other low-income countries, has an increasing cancer burden that remains underestimated. Infection-associated malignancies, particularly HIV-infection, represent a great proportion of cancer bur...

    Julee A. Campbell, Amr S. Soliman, Crispin Kahesa, Sioban D. Harlow and Diwani Msemo

    Infectious Agents and Cancer 2016 11:58

    Published on: 21 November 2016

  9. Research Article

    Invasive cervical cancers in the United States, Botswana and Kenya: HPV type distribution and health policy implications

    More deaths occur in African women from invasive cervical cancer (ICC) than from any other malignancy. ICC is caused by infection with oncogenic types of human papillomavirus (HPV). Co-infection with the human...

    Aaron Ermel, Brahim Qadadri, Yan Tong, Omenge Orang’o, Benson Macharia, Doreen Ramogola-Masire, Nicola M. Zetola and Darron R. Brown

    Infectious Agents and Cancer 2016 11:56

    Published on: 11 November 2016

  10. Research Article

    Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

    Chronic Hepatitis B infection is a major health problem in Republic of Congo therefore molecular analysis of HBV strains is important to detect the patients at high risk of disease progression.

    Brunel Monic Angounda, Gildas Hoffman Ngouloubi, Amélia Bokilo Dzia, Luc Magloire Anicet Boumba, Warda Baha, Donatien Moukassa, Gabriel Ahombo, Moulay Mustapha Ennaji and Jean-Rosaire Ibara

    Infectious Agents and Cancer 2016 11:51

    Published on: 15 September 2016

  11. Research Article

    Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol’s iodine (VIA/VILI) in Libreville, Gabon

    The human papillomavirus (HPV) is the causative agent of cervical cancer, which is the leading cancer-related cause of death for women in Sub-Saharan Africa. In 2013, the Gabonese Ministry of Health and the Sy...

    Pamela Boundzanga Moussavou, Ismaël Hervé Koumakpayi, Andriniaina Andy Nkili-Meyong, Ingrid Labouba, Ulrich Bisvigou, Junie K. Chansi, Corinne Engohan-Aloghe, Frederic Dissanami, Nathalie Ambounda, Anne-Sophie Delannoy-Vieillard, Laure Diancourt, Dieudonne Nkoghe, Eric M. Leroy, Ernest Belembaogo and Nicolas Berthet

    Infectious Agents and Cancer 2016 11:50

    Published on: 7 September 2016

  12. Research Article

    Variability of high risk HPV genotypes among HIV infected women in Mwanza, Tanzania- the need for evaluation of current vaccine effectiveness in developing countries

    High risk (HR) human papilloma Virus (HPV) genotypes have been associated with cervical cancer. In Tanzania there is a limited data on the epidemiology of HPV and genotypes distribution among HIV infected wome...

    Fridolin Mujuni, Mariam M. Mirambo, Peter Rambau, Korn Klaus, Muller Andreas, Dismas Matovelo, Mtebe Majigo, Christa Kasang and Stephen E. Mshana

    Infectious Agents and Cancer 2016 11:49

    Published on: 19 August 2016

  13. Research Article

    Human papillomavirus genotypes distribution in cervical cancer cases in Gabon

    Cervical cancer is a real public health problem in African countries. The relation between HPV and cervical cancer is well established. However, it is known that the distribution of HPV genotypes differ geogra...

    Samira Zoa-Assoumou, Angelique Ndjoyi-Mbiguino, Barthelemy Mabika Mabika, Ernest Belembaogo, Abdelkim Khattabi and My Mustapha Ennaji

    Infectious Agents and Cancer 2016 11:42

    Published on: 16 August 2016

  14. Research Article

    Diversity of high risk human papilloma viruses in women treated with antiretroviral and in healthy controls and discordance with cervical dysplasia in the South of Benin

    High risk oncologic Human Papilloma Virus (HPV) is one of the leading causes of cervical cancer worldwide. We investigated HPV genotypes among women living or not with Human Immuno-deficiency Virus (HIV) in tw...

    Callinice D. Capo-chichi, Blanche Aguida, Nicodème W. Chabi, Jocelyn Acapko-Ezin, Jonas Sossah-Hiffo, Vidéhouénou K. Agossou, Toussain Anagbla, Marcel Zannou, Fabien Houngbé and Ambaliou Sanni

    Infectious Agents and Cancer 2016 11:43

    Published on: 15 August 2016

  15. Review

    A review of the infection-associated cancers in North African countries

    Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma viru...

    Wafaa Mohamed Hussein, Wagida A. Anwar, Mohammed Attaleb, Loubna Mazini, Asta Försti, Roxana-Delia Trimbitas and Meriem Khyatti

    Infectious Agents and Cancer 2016 11:35

    Published on: 10 August 2016

  16. Research Article

    Cancer of the vulva in Burkina Faso: a hospital-based case series

    Vulvar cancer is a rare gynaecological cancer. In Burkina Faso, the diagnosis of vulvar cancers is delayed and the prognosis is poor. However, no specific study on vulvar cancers has been conducted at the mome...

    Nayi Zongo, Nina Korsaga-Somé, Amandine Banata Gang-Ny, Edgar Ouangré, Maurice Zida, Aimé Sosthène Ouédraogo, Aboubacar Hirrhum Bambara, Augustin Tozoula Bambara, Si Simon Traore, Pascal Niamba, Adama Traoré and Ahmadou Dem

    Infectious Agents and Cancer 2016 11:33

    Published on: 3 August 2016

  17. Research Article

    The pattern of prognostic and risk indicators among women with breast cancer undergoing modified radical mastectomy in Dar es Salaam, Tanzania

    Breast cancer is the commonest female malignancy globally and the second (after uterine cervix) in sub-Saharan Africa including Tanzania. Prognostic indicators reportedly influence post-mastectomy adjuvant the...

    Amos R. Mwakigonja, Happiness Rabiel, Naboth A. Mbembati and Leonard E. K. Lema

    Infectious Agents and Cancer 2016 11:28

    Published on: 30 June 2016

  18. Research Article

    Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons

    Human herpesvirus-8 (HHV-8), the etiologic agent of Kaposi sarcoma (KS), establishes lifelong latent infection with periodic lytic replication (“shedding”) at mucosal sites, especially the oropharynx. Patterns...

    Rachel A. Bender Ignacio, Jason D. Goldman, Amalia S. Magaret, Stacy Selke, Meei-Li Huang, Soren Gantt, Christine Johnston, Warren T. Phipps, Joshua T. Schiffer, Richard A. Zuckerman, R. Scott McClelland, Connie Celum, Larry Corey, Anna Wald and Corey Casper

    Infectious Agents and Cancer 2016 11:7

    Published on: 10 February 2016

  19. Research Article

    p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya

    The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries.

    Caroline Wangari Ngugi, Dietmar Schmidt, Karanja Wanyoro, Hamadi Boga, Peter Wanzala, Anne Muigai, John Mbithi, Magnus von Knebel Doeberitz and Miriam Reuschenbach

    Infectious Agents and Cancer 2015 10:25

    Published on: 11 August 2015

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