Fig. 1

EPRS1 was upregulated in liver cancer and correlated with poor prognosis. A, Expression of 19 cytosolic ARSs in TCGA-LIHC cohort. B, Volcanic map of 19 differentially expressed cytosolic ARSes. C, EPRS1 mRNA levels upregulated in tumor samples from TCGA-LIHC. D, Kaplan-Meier curves for five-year overall survival (left) and disease-specific survival (right) according to EPRS1 expression of patients with liver cancer from the TCGA-LIHC dataset. E, Association between EPRS1 expression and clinicopathological factors in liver cancer. F, Volcano map of EPRS1 expression in GSE14520 (GPL3921) dataset. G, EPRS1 expression in 225 hepatitis B virus-related HCC and 220 non-tumor tissues (left), or 213 paired tumor and non-tumor tissues from the GSE14520 dataset. H, Kaplan-Meier curves for overall survival (left) and recurrence-free survival (right) of patients with liver cancer from the GSE14520 dataset according to EPRS1 expression. I, Correlation between EPRS1 expression and clinicopathological factors in liver cancer from the GSE14520 dataset. J, ROC analysis indicated that EPRS1 mRNA levels were specific and sensitive biomarkers for HCC detection in both TCGA-LIHC (left) and GSE14520 (right) datasets. K, High EPRS1 expression in other tumors in the TCGA database