Fig. 4

Microendoscopic pictures and H&E stained sections of HSIL and early cervical cancer patients were compared. Microendoscopy can reveal cellular features displayed in histological sections. (a-b) Abundant supramucoid cells were observed. The cytoplasm was full of mucus, and the nuclei were deeply stained, which were biased to the inner side of the cytoplasm under the microendoscopy (a) and tissue section (b) in the cervical canal of HSIL patients. (c-d) Abnormal columnar epithelial cells in a patient with adenocarcinoma in situ were observed in the cervical canal, with enlarged nuclei, intense staining, and neatly arranged feathers under microendoscopy (c) and H&E stained tissue pathological sections (d). (e-f) Squamous cell carcinoma of early cervical cancer patients showed heterogeneous features such as nuclear enlargement, hyperchromasia, and mitotic figures under microendoscopy (e) and H&E stained tissue pathological sections (f). All histopathology images were taken at the same magnification of × 400