Skip to main content
Fig. 2 | Infectious Agents and Cancer

Fig. 2

From: Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases

Fig. 2

POWV infection and innate immune response for the neuroinflammatory response. Powassan virus (POWV) directly infects Mφ at early onset causing indirect activation of natural killer (NK), NKT, CD8+ T, and B cells. That infection triggers a protective innate immune response that results in the production of IFNγ, IgM antibodies, and cytolytic proteins including perforin and granzyme B. These factors together cause cytotoxicity of POWV particles (#1). Excessive production of IFNγ turns on the activation of microglial cells. Subsequent release of chemokines attracts inflammatory Th1 cells through the blood–brain barrier (BBB) and causes a demyelinating response in CNS (#2)

Back to article page