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Table 1 Studies on the detection of Epstein–Barr virus by ISH in patients with primary gastric lymphoma

From: Estimating the prevalence of Epstein–Barr virus in primary gastric lymphoma: a systematic review and meta-analysis

Reference (Year), Country

Threshold for EBV positivity by ISH (% of tumour cells)

Gastric MALT lymphoma

Gastric DLBCL

EBV positive/total

EBV positive/ total by subtype

H. pylori positive/total (by subtype)

EBV positive/total

EBV

positive/ total by morphology

H. pylori positive/total

Ott et al. [17] (1993), Germany

N/A

0/27

N/A

N/A

2/24

Centroblastic: 2/22 Immunoblastic: 0/2

N/A

Liu et al. [18] (1995), Japan

N/A

2/16

N/A

N/A

2/33

Centroblastic:2/30

Immunoblastic:0/3

N/A

Futamura et al. [19] (1996), Japan

 ≥ 5

1/32

Low grade: 1/23

High grade: 0/9

N/A

1/9

N/A

N/A

Narita et al. [20] (1996), Japan

N/A

1/5

N/A

N/A

1/8

N/A

N/A

Lee et al. [21] (1997), Republic of Korea

 > 50

0/8

N/A

N/A

5/43

N/A

N/A

Xu et al. [22] (1997), China (Hong Kong)

N/A

0/40

Low grade: 0/13

High grade: 0/27

22/40

Low grade:8/13

High grade: 14/27

1/13

N/A

7/13

Yang et al. [23] (1998), Republic of Korea

N/A

0/19

Low grade: 0/12

High grade: 0/7

N/A

1/13

N/A

N/A

Ben Rejeb et al. [24] (1999), Tunisia

N/A

3/15

N/A

N/A

N/A

N/A

N/A

Chan et al. [25] (2001), China (Hong Kong)

 > 90

0/29

Low grade: 0/14

High grade: 0/15

29/29

10/17

N/A

6/17

Peh [26] (2001), Malaysia

 > 50

0/3

Low grade: 0/1

High grade: 0/2

N/A

0/7

N/A

N/A

Ishikawa et al. [27] (2019), Japan

 ≥ 80

N/A

N/A

N/A

25/240

N/A

49/72

Zhou et al. [28] (2020), China

 > 80

N/A

N/A

N/A

22/236

N/A

N/A

  1. EBV = Epstein–Barr virus; H. pylori = Helicobacter pylori; MALT lymphoma = mucosa-associated lymphoid tissue lymphoma; DLBCL = diffuse large B-cell lymphoma; ISH = in-situ hybridisation; N/A = information not available