Table 7 The clinical characteristics of patients with thyroid dysfunction caused by PD-1 monoclonal antibody therapy classified as grade 3 by CTCAE

1

M

67

S*

HBV

Yes

Yes

C

TACE, Targeted agent

No detect

2

F

70

C**

No

No

–

C

None

Negative

3

M

43

C

HBV

Yes

Yes

C

TACE

Negative

4

F

49

C

HBV

No

–

C

TACE, Tumor ablation, Systemic chemotherapy

No detect

5

M

62

C

HBV

Yes

No

C

Surgical resection, TACE, Tumor ablation, Targeted agent, Radiotherapy

TPO, TG positive

6

F

58

C

HBV

Yes

No

C

TACE, Tumor ablationTargeted agent, Radiotherapy

No

7

M

58

C

HBV

Yes

No

C

TACE, Tumor ablation, Targeted agent

No

8

M

67

C

HBV

Yes

No

B

TACE, Tumor ablation, Targeted agent

No

9

M

47

C

HBV

Yes

No

B

Surgical resection, TACE, Tumor ablation

No

10

M

84

C

HBV

Yes

Yes

C

Targeted agent

TPO, TG positive