Fig. 1From: EBV persistence in gastric cancer cases conventionally classified as EBER-ISH negativeHistological and in situ hybridization findings. (A–C) Gastric adenocarcinoma; the tumor is composed of dilated or branching tubules invading the muscle layer HE (A), EBER-ISH negative (B), EBER-ISH positive; EBV-encoded small ribonucleic acid (EBER1) in situ hybridization shows positive nuclei in the neoplastic glands whereas the stroma remain unlabeled (C); (D–F) Gastric carcinoma with lymphoid stroma; cancer cells forming small nests or fused glands, accompanied by abundant lymphocyte infiltration HE (D), EBER-ISH negative (E), EBER-ISH positive; nuclei of carcinoma cells are positive by in situ hybridization targeting EBER, but the infiltrating lymphocytes are negative (F). (Original magnification 10X)Back to article page