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Fig. 1 | Infectious Agents and Cancer

Fig. 1

From: EBV persistence in gastric cancer cases conventionally classified as EBER-ISH negative

Fig. 1

Histological and in situ hybridization findings. (AC) Gastric adenocarcinoma; the tumor is composed of dilated or branching tubules invading the muscle layer HE (A), EBER-ISH negative (B), EBER-ISH positive; EBV-encoded small ribonucleic acid (EBER1) in situ hybridization shows positive nuclei in the neoplastic glands whereas the stroma remain unlabeled (C); (DF) Gastric carcinoma with lymphoid stroma; cancer cells forming small nests or fused glands, accompanied by abundant lymphocyte infiltration HE (D), EBER-ISH negative (E), EBER-ISH positive; nuclei of carcinoma cells are positive by in situ hybridization targeting EBER, but the infiltrating lymphocytes are negative (F). (Original magnification 10X)

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