| Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95%CI) | p value | HR (95% CI) | p value | |
Age, years (> 60 vs ≤ 60) | 0.948 (0.628–1.432) | 0.800 |  |  |
Gender (Male vs Female) | 1.246 (0.718–2.162) | 0.435 |  |  |
ALT, IU/ml (> 40 vs ≤ 40) | 0.811 (0.533–1.234) | 0.329 |  |  |
AST, IU/ml (> 40 vs ≤ 40) | 1.162 (0.777–1.737) | 0.465 |  |  |
ALP, IU/L (> 130 vs ≤ 130) | 1.268 (0.812–1.980) | 0.297 |  |  |
ALB, g/L (< 35 vs ≥ 35) | 1.249 (0.763–2.046) | 0.376 |  |  |
Total bilirubin, µmol/L (> 17 vs ≤ 17) | 1.236 (0.824–1.855) | 0.306 |  |  |
PT, s (≥13 vs < 13) | 2.269 (1.418–3.631) | 0.001 | 1.954 (1.193-3.200) | 0.008 |
AFP, ng/ml (≥20 vs < 20) | 2.117 (1.361–3.291) | 0.001 | 2.498 (1.538–4.057) | < 0.001 |
PLT, 109/L (≥100 vs < 100) | 1.648 (1.030–2.635) | 0.037 | 1.756 (1.087–2.838) | 0.021 |
Satellite nodules (yes vs no) | 1.491 (0.910–2.442) | 0.113 |  |  |
Capsular (yes vs no) | 1.743 (1.121–2.711) | 0.014 | 1.565 (0.986–2.484) | 0.057 |
Moderate/poor tumor differentiation (yes vs no) | 1.812 (1.212–2.710) | 0.004 | 1.437 (0.953–2.166) | 0.084 |
Vascular invasion (yes vs no) | 2.495 (1.643–3.788) | < 0.001 | 1.020 (0.605–1.722) | 0.940 |
Tumor size, cm (> 5 vs ≤ 5) | 3.898 (2.418–6.284) | < 0.001 | 3.035 (1.310–7.034) | 0.010 |
Multiple tumor (yes vs no) | 2.881 (1.833–4.528) | < 0.001 | 1.903 (1.095–3.307) | 0.023 |
Cirrhosis (yes vs no) | 1.384 (0.886–2.161) | 0.154 |  |  |
Hypertension (yes vs no) | 0.783 (0.486–1.261) | 0.315 |  |  |
Diabetes mellitus (yes vs no) | 1.028 (0.608–1.737) | 0.918 |  |  |
History of smoking (yes vs no) | 1.050 (0.696–1.582) | 0.817 |  |  |
Alcohol abuse (yes vs no) | 0.987 (0.649–1.501) | 0.950 |  |  |
HBeAg positive (yes vs no) | 1.387 (0.847–2.272) | 0.193 |  |  |
Child–Pugh score (B vs A) | 3.126 (0.989–9.878) | 0.052 |  |  |
BCLC stage (B-C vs 0-A) | 4.134 (2.445–6.989) | < 0.001 | 1.042 (0.396–2.744) | 0.933 |
Antiviral therapy (yes vs no) | 0.488 (0.323–0.737) | 0.001 | 0.431 (0.274–0.679) | < 0.001 |