| Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Age, years (> 60 vs ≤ 60) | 0.867 (0.637–1.178) | 0.362 |  |  |
Gender (Male vs Female) | 1.127 (0.760–1.670) | 0.552 |  |  |
ALT, IU/ml (> 40 vs ≤ 40) | 1.040 (0.769–1.406) | 0.801 |  |  |
AST, IU/ml (> 40 vs ≤ 40) | 1.559 (1.156–2.102) | 0.004 |  |  |
ALP, IU/L (> 130 vs ≤ 130) | 1.704 (1.240–2.340) | 0.001 | 1.820 (1.302–2.545) | < 0.001 |
ALB, g/L (< 35 vs ≥ 35) | 1.027 (0.697–1.515) | 0.892 |  |  |
Total bilirubin, µmol/L (> 17 vs ≤ 17) | 1.377 (1.019–1.860) | 0.037 |  |  |
PT, s (≥ 13 vs < 13) | 1.845 (1.249–2.725) | 0.002 |  |  |
AFP, ng/ml (≥ 20 vs < 20) | 1.773 (1.300-2.419) | < 0.001 | 2.124 (1.506–2.995) | < 0.001 |
PLT, 109/L (≥ 100 vs < 100) | 1.385 (0.997–1.924) | 0.052 |  |  |
Satellite nodules (yes vs no) | 1.956 (1.366–2.802) | < 0.001 | 1.290 (0.869–1.914) | 0.206 |
Capsular (yes vs no) | 1.598 (1.137–2.247) | 0.007 |  |  |
Moderate/poor tumor differentiation (yes vs no) | 1.658 (1.226–2.242) | 0.001 | 1.462 (1.067–2.002) | 0.018 |
Vascular invasion (yes vs no) | 2.325 (1.678–3.221) | < 0.001 | 1.247 (0.814–1.910) | 0.311 |
Tumor size, cm (> 5 vs ≤ 5) | 2.441(1.789–3.329) | < 0.001 | 1.606 (0.894–2.885) | 0.113 |
Multiple tumor (yes vs no) | 2.630(1.823–3.796) | < 0.001 | 1.815 (1.170–2.815) | 0.008 |
Cirrhosis (yes vs no) | 1.396 (1.009–1.933) | 0.044 |  |  |
Hypertension (yes vs no) | 1.151 (0.830–1.596) | 0.400 |  |  |
Diabetes mellitus (yes vs no) | 1.114 (0.762–1.627) | 0.578 |  |  |
History of smoking (yes vs no) | 1.197 (0.887–1.616) | 0.240 |  |  |
Alcohol abuse (yes vs no) | 1.208 (0.890–1.638) | 0.225 |  |  |
HBeAg positive (yes vs no) | 1.110 (0.753–1.638) | 0.597 |  |  |
Child–Pugh score (B vs A) | 2.208 (0.819–5.954) | 0.118 |  |  |
BCLC stage (B-C vs 0-A) | 2.649 (1.908–3.678) | < 0.001 | 1.148 (0.591–2.231) | 0.683 |
Antiviral therapy (yes vs no) | 0.620 (0.460–0.835) | 0.002 | 0.529 (0.377–0.741) | < 0.001 |