Hepatitis B or C viral infection and the risk of cervical cancer

Table 5 Modification effect of HPV infection between the association of HBV and the risk of cervical cancer with stratified analyses

Variable	Cases		Controls		Univariate analyses			Multivariate analyses
	(n = 838)		(n = 838)		Univariate analyses			Multivariate analyses
	No	%	No	%	OR	95%CI	P	AOR	95%CI	P
HBsAg and HPV
HBsAg-negative/HPV-negative	132	16	735	88		1(reference)			1(reference)
HBsAg-negative/HPV-positive	651	78	66	7.9	54.9	40.1–75.2	< 0.001	58.5	42.0–81.3	< 0.001
HBsAg-positive/HPV-negative	9	1.1	33	3.9	1.5	0.7–3.2	0.281	1.6	0.7–3.5	0.252
HBsAg-positive/HPV-positive	46	5.5	4	0.5	64.0	22.7–180.9	< 0.001	67.1	23.4–192.7	< 0.001
P_interaction							0.69			0.636
Anti-HBc and HPV
Anti-HBc-negative/HPV-negative	115	14	682	81		1(reference)			1(reference)
Anti-HBc-negative/HPV-positive	573	68	58	6.9	58.6	41.9–81.9	< 0.001	59.1	42.0–83.3	< 0.001
Anti-HBc-positive/HPV-negative	26	3.1	86	10	1.8	1.1–2.9	0.017	1.8	1.1–3.0	0.018
Anti-HBc-positive/HPV-positive	124	15	12	1.4	61.3	32.8–114.4	< 0.001	59.5	31.6–112.2	< 0.001
P_interaction							0.192			0.159

P-values in bold denoted statistical significance for P ＜0.05
Multivariate analyses were adjusted by age (as a continous variable), ethnicity (Han/non-Han), birth of place (Yunnan and neighboring province/Other provinces in China) and No. full-term pregnancies(0/1/2/3/ > 3)
HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; anti-HBc, hepatitis B core antibody; OR, odds ratio; AOR, adjusted odds ratio; CI: confidence interval

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