Are Blastocystis hominis and Cryptosporidium spp. playing a positive role in colorectal cancer risk? A systematic review and meta-analysis

Table 2 Summary of the included studies reporting prevalence of Cryptosporidium spp. in CRC patients

References	Country	Study design	Diagnostic methods	Statistical significant difference	Total case	Positive case	Cryptosporidium species-subtypes in case group	Total control	Positive control	QA
Zhang et al. [6]	China	CC*	PCR	Significant differences (p value < 0.001)	116	20	C. parvum-IIaA15G2R1 (10), C. parvum-IIaA15G2R2 (9), and C. parvum-IIaA13G2R2 (1)	141	0	10
Sulzyc Bielicka et al. [7]	Poland	CC	Immunoenzymatic test	Significant differences (p value = 0.015)	108	14		125	5	10
Essid et al. [35]	Tunisia	CS*	Modified Ziehl Neelsen stain and PCR		15	5	C. hominis-IaA27G1R1 (2), C. parvum-IIaA15G2R1 (1), and C. parvum-IIcA5G3 (2)			7
Shebl et al. [36]	United States	CS	Microscopic		320	7				7
Sulzyc Bielicka et al. [37]	Poland	CS	Immunoenzymatic test		87	11				6
Sulzyc Bielicka et al. [38]	Poland	CS	Enzyme immunoassay		55	10				6

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