Fig. 2

a MiRNA profiling on EV_K16 compared to EV_K16sil. Results were expressed as fold of induction or decrease using the 2^−ΔΔCT method, and EV_K16 sil., as a reference. According to the 2^−ΔΔCT method, the value of non-deregulated miRNAs was set to 1. The miRNAs not showing variation in the expression between EV_K16 and EV_K16 sil. are positioned on the value equal to one. The selected and deregulated miRNAs are indicated with black dots; non-deregulated miRNAs are plotted with gray dots. b Principal Component Analysis conducted on ΔCts derived from the analysis of EV_K16, EV_K16 sil., K16, keratinocytes and monocytes used as controls. Each dot represents the variance of 62 miRNAs selected from the previous analysis on EV_K16, for each reference cell population (EV_K16, EV_K16 sil., K16 and HFK). PCA was performed by using ClustVis (https://biit.cs.ut.ee/clustvis/) algorithm