Fig. 1

a MiRNA profiling in K49 compared to HFK cells. MiRNA analysis was performed using the TaqMan Array Human MicroRNA A Card. Results were expressed as fold of induction using the 2^−ΔΔCT method [28] and HFK as a reference. According to the 2^−ΔΔCT method, the value of non-deregulated MiRNAs was set to 1. Deregulated and selected miRNAs are indicated with black dots; non-deregulated miRNAs are plotted with gray dots. b Principal Component Analysis performed on ΔCts derived from the analysis of K16, K38, K49, K76 and HFK used as controls. Each dot represents the variance of 35 miRNAs, selected from the previous analysis on K49 cells, for each reference cell population (K16, K38, K49, K76 andHFK). PCA was performed by using ClustVis (https://biit.cs.ut.ee/clustvis/) algorithm