Arterial chemoembolization for patients with hepatocellular carcinoma and elevated lactate dehydrogenase is associated with low survival: a cohort study

Table 6 Use the two-piece Cox proportional hazard model to perform a threshold effect analysis on the ΔLDH in the deduction cohort

	Unadjusted HR (95% CI)	Adjusted HR (95% CI)^#
The one-line Cox proportional hazards model	1.02 (0.98, 1.06)	1.01 (0.98, 1.05)
The two-piece-wise Cox proportional hazards model
< 0 (80U/L)	0.96 (0.93, 1.00)	0.98 (0.94, 1.02)
> 0 (80U/L)	1.11 (1.07, 1.15)	1.06 (1.02, 1.11)
P for log-likelihood ratio test	< 0.001	0.021

One-line linear regression is compared with the log-likelihood ratio test. #This model was adjusted based on Gender(Male, Female), PS score (0, 1), age (< 55, ≥ 55), Child–Pugh class (A, B), location of lesions (none, left/right, both), diameter of main tumour (< 5, ≥ 5), No.of intrahepatic lesions (0, ≤ 3, > 3), and AFP (< 25, ≥ 25), Hgb (g/L)(< 120, ≥ 120), WBC (109/L)(< 11, ≥ 11)

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