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Table 8 Comparison of different screening strategies

From: Verification of the association of the cycle threshold (Ct) values from HPV testing on Cobas4800 with the histologic grades of cervical lesions using data from two population-based cervical cancer screening trials

Algorithms

CIN2+ (n = 180)

CIN3+ (n = 74)

Colposcopy referral rate%

Cytology testing rate%

Colposcopies to detect 1 CIN2+ /CIN3+ 

Sen%

Spe%

Sen%

Spe%

A. HPV16-plus/18-plus

53.3*

75.7*

70.3*

74.3*

28.1

NA

4.0/7.4

B. Cytology ≥ ASCUS

80.0*

66.7*

97.3

63.9*

39.4

100

3.8/7.5

C. Cytology ≥ LSIL

66.1*

84.7*

89.2*

81.9*

22.0

100

2.6/4.6

D. HPV16-plus/18-plus+ cytology ≥ ASCUS for pooled 12-HPV

90.6

49.6

100

46.9

55.6

72.0

4.7/10.3

E. HrHPV CtV ≤ 33.2

85.0

39.5*

91.9*

37.9*

63.7

NA

5.7/12.9

F. HPV16-plus/18-plus+ CtV ≤ 33.2 for pooled 12-HPV

89.4

29.7*

93.2

28.4*

72.8

NA

6.2/14.5

  1. hrHPV positive, n = 1375
  2. *Compared with algorithm D, P < 0.05
  3. One woman with invalid cytology result was excluded in the analysis