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Table 6 Relative risks (RRs) of CIN2+ and CIN3+ for low-Ct HPV positive cases relative to high-Ct HPV positive cases

From: Verification of the association of the cycle threshold (Ct) values from HPV testing on Cobas4800 with the histologic grades of cervical lesions using data from two population-based cervical cancer screening trials

Factors

Absolute risks for CIN2+ (%)

Relative risks for CIN2+ (95% CI)

Absolute risks for CIN3+ (%)

Relative risk for CIN3+ (95% CI)

hrHPV

13.1 (180/1376)

 

5.4 (74/1376)

 

 CtV > 33.2

5.4 (27/500)

1

1.2 (6/500)

1

 CtV ≤ 33.2

17.5 (153/876)

3.2 (2.18–4.80)

7.8 (68/876)

6.5 (2.83–14.80)

HPV16-plus

31.6 (89/282)

 

17.7 (50/282)

 

 Ct > 37.4

2.4 (1/41)

1

0 (0/41)

NA

 30.3 < CtV ≤ 37.4

12.5 (11/88)

5.1 (0.68–38.38)

3.4 (3/88)

1

 CtV ≤ 30.3

50.3 (77/153)

20.6 (2.96–143.92)

30.7 (47/153)

9.0 (2.89–28.10)

Pooled 12-HPV

8.5 (84/990)

 

2.2 (22/990)

 

 CtV > 29.6

5.7 (34/601)

1

1.3 (8/601)

1

 CtV ≤ 29.6

12.9 (50/389)

2.3 (1.50–3.45)

3.6 (14/389)

2.7 (1.15–6.39)

  1. Absolute risks for CIN2+ or CIN3+ is the number of subjects with CIN2+ or CIN3+ /number of subjects with positive test results
  2. CI confidence interval, NA not applicable