Verification of the association of the cycle threshold (Ct) values from HPV testing on Cobas4800 with the histologic grades of cervical lesions using data from two population-based cervical cancer screening trials

Table 4 Comparison of the Ct values of hrHPV/HPV16 between single infection and coinfection

Histology grade	hrHPV single infection		hrHPV coinfection		HPV16 single infection		HPV16 coinfection
Histology grade	No. of participants	CtV (mean ± SD)	No. of participants	CtV (mean ± SD)	No. of participants	CtV (mean ± SD)	No. of participants	CtV (mean ± SD)
Non-CIN	936	31.8 (± 5.1)	63	32.8 (± 4.3)	111	32.2 (± 4.7)	45	32.9 (± 4.5)
CIN1	184	29.3 (± 5.8)^a	13	33.3 (± 4.1)	26	30.8 (± 6)	11	32.9 (± 3.8)
CIN2	84	28.8 (± 5.1)^a	22	29.1 (± 5.1)	20	28.3 (± 3.9)^a	19	27.6 (± 3.6)^a,b
CIN3+	59	27.3 (± 4.5)^a	15	27.0 (± 2.5)^a,b	36	26.2 (± 3.4)^a,b	14	26.6 (± 2.2)^a,b

^aCompared with non-CIN, P < 0.05
^bCompared with CIN1, P < 0.05
HrHPV single infection refers to a result that is positive of HPV16 only, or HPV18 only, or pooled 12-HPV. HrHPV coinfection refers to a result that is positive of at least two of HPV16, HPV18, and pooled 12-HPV. HPV16 single infection refers to a result that is positive of HPV16 only. HPV16 coinfection refers to a result that is positive of HPV16, plus HPV18 and/or pooled 12-HPV

ISSN: 1750-9378