Verification of the association of the cycle threshold (Ct) values from HPV testing on Cobas4800 with the histologic grades of cervical lesions using data from two population-based cervical cancer screening trials

Table 3 Comparison of the Ct values for specific HPV genotype among different grades of cervical lesions

Histology grade	HrHPV		HPV16-plus		HPV18-plus		Pooled 12-HPV
Histology grade	No. of participants	CtV (mean ± SD)	No. of participants	CtV (mean ± SD)	No. of participants	CtV (mean ± SD)	No. of participants	CtV (mean ± SD)
Non-CIN	999	31.9 (± 5.1)	156	32.4 (± 4.6)	87	32.1 (± 4.7)	756	31.8 (± 5.2)
CIN1	197	29.6 (± 5.8)	37	31.5 (± 5.4)	10	33.3 (± 5.4)	150	28.9 (± 5.7)^a
CIN2+	180	28.2 (± 4.8)^a,b	89	27.0 (± 3.4)^a,b	7	34.4 (± 5.6)	84	28.9 (± 5.5)^a
CIN3+	74	27.2 (± 4.2)^a,b	50	26.3 (± 3.1)^a,b	2	29.2 (± 3.8)	22	29.1 (± 5.7)

^aCompared with non-CIN, P < 0.05
^bCompared with CIN1, P < 0.05
HPV16-plus refers to a result that is positive of HPV16 only or positive of HPV16 plus 18 and/or pooled 12-HPV; HPV18-plus refers to a result that is positive of HPV18 positive only or positive of HPV18 plus pooled 12-HPV
CIN2+ includes CIN2, CIN3 and cancer. CIN3+ includes CIN3 and cancer

ISSN: 1750-9378