Fig. 4

PRKRA expression levels are associated with EIF2AK2 and inflammatory cytokines. A, B The positive correlation between PRKRA expression levels and EIF2AK2 expression levels in tissues (A) and peripheral blood samples (B). C, D Heatmaps indicating the associations across PRKRA, EIF2AK2 and inflammatory cytokines genes. Pearson r and p values shown in C, D, respectively. Data were derived from TCGA database. E A schematic illustration of PRKRA upregulation was associated with EIF2AK2 and inflammation, which explain the possible reasons for poor prognosis in HBV-related HCC