Table 3 Seroprevalence of antibodies to HPV-16 and- 18 L1, E6 and E7 proteins in infection unrelated cancer controls in HIV-positive women
Characteristics | Â | Serology markers | |||||||
|---|---|---|---|---|---|---|---|---|---|
Total | Â | Â | HPV-16 | HPV-18 | |||||
N = 667 | HPV-16 L1 (%) | HPV-18 L1 (%) | E6 (%) | E7 (%) | E6 & E7 (%) | E6 (%) | E7 (%) | E6 & E7 (%) | |
Overall seroprevalence | Â | 15.9 | 15.7 | 2.4 | 3.3 | 0.5 | 1.5 | 3.2 | 0.2 |
Demographic | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Age | Â | Â | Â | Â | Â | Â | Â | Â | Â |
25–34 | 136 | 24 (17.7) | 15 (11.0) | 5 (3.7) | 5 (3.7) | 1 (0.8) | 1 (0.7) | 1 (0.7) | 0 (0.0) |
35–44 | 300 | 42 (14.0) | 50 (16.7) | 7 (2.3) | 12 (4.0) | 1 (0.4) | 5 (1.7) | 10 (3.3) | 0 (0.0) |
45–54 | 231 | 40 (17.3) | 40 (17.3) | 4 (1.7) | 5 (2.2) | 1 (0.5) | 4 (1.7) | 10 (4.3) | 1 (0.5) |
Chi-square trend (p value) | Â | 0.896 | 0.137 | 0.254 | 0.191 | 0.719 | 0.490 | 0.067 | 0.236 |
Place of residence | |||||||||
Rural | 28 | 2 (7.1) | 4 (14.3) | 0 (0.0) | 1 (3.6) | 0 (0.0) | 1 (3.6) | 1 (3.6) | 0 (0.0) |
Urban | 639 | 104 (16.3) | 101 (15.8) | 16 (2.5) | 21 (3.3) | 3 (0.5) | 9 (1.4) | 20 (3.1) | 1 (0.2) |
Chi-square heterogeneity age-adjusted (p value) | Â | 0.218 | 0.797 | 0.399 | 0.982 | 0.724 | 0.376 | 0.912 | 0.856 |
Period of interview | |||||||||
1995–1999 | 7 | 1 (14.3) | 1 (14.3) | 1(14.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
2000–2004 | 90 | 9 (10.0) | 11 (12.2) | 4 (4.4) | 4 (4.4) | 1 (1.2) | 3 (3.3) | 1 (1.1) | 1 (1.1) |
2005–2009 | 230 | 32 (13.9) | 36 (15.7 | 5 (2.2) | 7 (3.0) | 0 (0.0) | 4 (1.7) | 7 (3.0) | 0 (0.0) |
2010–2016 | 340 | 64 (18.8) | 57 (16.8) | 6 (1.8) | 11 (3.2) | 2 (0.6) | 3 (0.8) | 13 (3.8) | 0 (0.0) |
Chi-square heterogeneity age-adjusted (p value) | Â | 0.138 | 0.872 | 0.109 | 0.898 | 0.572 | 0.287 | 0.701 | 0.036 |
Marital Status | |||||||||
Never Married | 231 | 38 (16.5) | 36 (15.6) | 4 (1.7) | 4 (1.7) | 0 (0.0) | 1 (0.4) | 5 (2.2) | 0 (0.0) |
Married | 257 | 32 (12.5) | 35 (13.6) | 8 (3.1) | 12 (4.7) | 1 (0.4) | 4 (1.6) | 8 (3.1) | 0 (0.0) |
Ever married | 179 | 36 (20.1) | 34 (19.0) | 4 (2.2) | 6 (3.4) | 2 (1.2) | 5 (2.8) | 8 (4.5) | 1 (0.6) |
Chi-square heterogeneity age-adjusted (p value) | Â | 0.101 | 0.448 | 0.573 | 0.171 | 0.178 | 0.188 | 0.673 | 0.488 |
Education Level | |||||||||
None | 24 | 2 (7.4) | 1 (3.7) | 1 (3.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Primary | 134 | 21 (15.7) | 23 (17.2) | 2 (1.5) | 3 (2.2) | 0 (0.0) | 4 (3.0) | 4 (3.0) | 0 (0.0) |
Secondary and above | 505 | 83 (16.4) | 81 (16.0) | 13 (2.6) | 19 (3.8) | 3 (0.6) | 6 (1.2) | 17 (3.4) | 1 (0.2) |
Chi-square adjusted for age trend (p value) | Â | 0.380 | 0.169 | 0.731 | 0.543 | 0.611 | 0.339 | 0.416 | 0.701 |
Sexual/ reproductive history | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Parity | |||||||||
0 | 22 | 9 (40.9) | 5 (22.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
1 | 142 | 20 (14.1) | 15 (10.6) | 3 (2.1) | 7 (4.9) | 0 (0.0) | 0 (0.0) | 1 (0.7) | 0 (0.0) |
2 | 188 | 38 (20.2) | 30 (16.0) | 6 (3.2) | 8 (4.3) | 2 (1.1) | 3 (1.6) | 8 (4.3) | 1 (0.6) |
3 | 148 | 17 (11.5) | 27 (18.2) | 3 (2.0) | 5 (3.4) | 1 (0.7) | 4 (2.7) | 7 (4.7) | 0 (0.0) |
4 +  | 131 | 17 (13.0) | 21 (16.0) | 3 (2.3) | 2 (1.5) | 0 (0.0) | 2 (1.5) | 4 (3.1) | 0 (0.0) |
Chi-square adjusted for age trend (p value) | Â | 0.022 | 0.688 | 0.614 | 0.340 | 0.932 | 0.294 | 0.347 | 0.373 |
Number of sexual partners | |||||||||
0–1 | 21 | 3 (14.3) | 4 (19.1) | 1 (4.8) | 2 (9.5) | 0 (0.0) | 0 (0.0) | 1 (4.8) | 0 (0.0) |
2–5 | 355 | 55 (15.5) | 52 (14.7) | 5 (1.4) | 9 (2.5) | 0 (0.0) | 8 (2.3) | 8 (2.3) | 1 (0.3) |
6 +  | 109 | 20 (18.4) | 19 (17.4) | 5 (4.6) | 3 (2.8) | 1 (1.0) | 1 (0.9) | 3 (2.8) | 0 (0.0) |
Chi-square adjusted for age trend (p value) | Â | 0.869 | 0.875 | 0.260 | 0.518 | 0.041 | 0.143 | 0.291 | 0.602 |
Unknown | 182 | 28 (15.4) | 30 (16.5) | 5 (2.8) | 8 (4.4) | 2 (1.2) | 1 (0.6) | 9 (5.0) | 0 (0.0) |