Skip to main content

Table 2 Seroprevalence of antibodies to HPV-16 and- 18 L1, E6 and E7 proteins in infection unrelated cancer controls in HIV-negative women

From: HPV types 16/18 L1 E6 and E7 proteins seropositivity and cervical cancer risk in HIV-positive and HIV-negative black South African women

Characteristics

 

Serology markers

Total

  

HPV-16

HPV-18

N = 1865

HPV-16 L1

(%)

HPV-18 L1

(%)

E6

(%)

E7

(%)

E6 & E7

(%)

E6

(%)

E7

(%)

E6 & E7

(%)

Overall seroprevalence

 

14.3

16.3

2.9

4.0

0.5

2.4

2.5

0.2

Demographic

         

Age

25–34

206

25 (12.1)

34 (16.5)

2 (1.0)

5(2.4)

1 (0.5)

6 (2.9)

3 (1.5)

0 (0.0)

35–44

638

86 (13.5)

93 (14.6)

19 (3.0)

21 (3.3)

4 (0.7)

17 (2.7)

12 (1.9)

1 (0.2)

45–54

1021

156 (15.3)

177 (17.3)

33 (3.2)

49 (4.8)

3 (0.3)

21 (2.1)

32 (3.1)

3 (0.3)

Chi-square trend (p value)

 

0.166

0.352

0.133

0.053

0.472

0.345

0.067

0.358

Place of residence

Rural

139

18 (13.0)

20 (14.4)

9 (6.5)

12 (8.6)

2 (1.6)

3 (2.2)

11(7.9)

1 (0.8)

Urban

1772

248 (14.4)

284 (16.5)

44 (2.6)

63 (3.7)

6 (0.4)

41 (2.4)

35 (2.0)

3 (0.2)

Chi-square heterogeneity age-adjusted (p value)

 

0.406

0.512

0.202

0.005

0.042

0.886

 < 0.001

0.184

Period of interview

1995–1999

115

22 (19.1)

26 (22.6)

5 (4.4)

7 (6.1)

1 (1.0)

4 (3.5)

4 (3.5)

0 (0.0)

2000–2004

373

61 (16.4)

65 (17.4)

15 (4.0)

17 (4.6)

4 (1.2)

5 (1.3)

7 (1.9)

2 (0.6)

2005–2009

663

86 (13.0)

95 (14.3)

19 (2.9)

27 (4.1)

1 (0.2)

15 (2.3)

14 (2.1)

1 (0.2)

2010–2016

714

98 (13.7)

118 (16.5)

15 (2.1)

24 (3.4)

2 (0.3)

20 (2.8)

22 (3.1)

1 (0.16)

Chi-square heterogeneity age-adjusted (p value)

 

0.1757

0.123

0.202

0.455

0.142

0.368

0.538

0.454

Marital Status

Never Married

422

56 (13.3)

67 (15.9)

11 (2.6)

12 (2.4)

2 (0.5)

5 (1.2)

11 (2.6)

0 (0.0)

Married

1002

134 (13.4)

161 (16.1)

30 (3.0)

47 (4.7)

5 (0.5)

34 (3.4)

23 (2.3)

4 (0.4)

Ever married

437

75 (17.2)

75 (17.2)

13 (3.0)

16 (3.7)

1 (0.2)

5 (1.1)

13 (3.0)

0 (0.0)

Chi-square heterogeneity age-adjusted (p value)

 

0.227

0.926

0.976

0.278

0.814

0.007

0.798

0.180

Education Level

None

123

22 (17.9)

21(17.1)

6 (4.9)

2 (1.6)

0 (0.0)

4 (3.3)

5 (4.1)

0 (0.0)

Primary

411

54 (13.1)

61 (14.8)

9 (2.2)

20 (4.9)

1 (0.3)

10 (2.4)

8 (2.0)

1 (0.3)

Secondary and above

1329

191 (14.4)

222 (16.7)

38 (2.9)

52 (3.9)

7 (0.6)

30 (2.3)

34 (2.6)

3 (0.2)

Chi-square adjusted for age trend (p value)

 

0.406

0.543

0.298

0.276

0.630

0.654

0.400

0.838

Sexual/ reproductive history

         

Parity

0

34

4 (11.8)

5 (14.7)

2 (5.9)

1 (2.9)

1 (3.0)

0 (0.0)

1 (2.9)

0 (0.0)

1

316

30 (9.5)

44 (13.9)

10 (3.2)

15 (4.8)

4 (1.3)

11 (3.5)

9 (2.9)

1 (0.3)

2

485

68 (14.0)

77 (15.9)

18 (3.7)

15 (3.1)

1 (0.2)

13 (2.7)

11(2.3)

0 (0.0)

3

449

81 (18.0)

70 (15.6)

14 (3.1)

18 (4.0)

2 (0.5)

6 (1.3)

11 (2.6)

0 (0.0)

4 + 

486

67 (13.8)

88 (18.1)

9 (1.9)

23 (4.7)

0 (0.0)

12 (2.5)

14 (2.9)

3 (0.6)

Chi-square adjusted for age trend (p value)

 

0.143

0.181

0.031

0.931

0.006

0.610

0.738

0.356

Number of sexual partners

0–1

170

22 (12.9)

25 (14.7)

6 (3.5)

6 (3.5)

0 (0.0)

1 (0.6)

2 (1.2)

0 (0.0)

2–5

1116

161 (14.4)

182 (16.3)

36 (3.2)

53 (4.8)

7 (0.7)

28 (2.5)

31(2.8)

3 (0.3)

6 + 

204

32 (15.7)

32 (15.7)

5 (2.6)

6 (2.9)

1 (0.5)

9 (4.4)

5 (2.5)

0 (0.0)

Chi-square adjusted for age trend (p value)

 

0.908

0.522

0.133

0.132

0.339

0.796

0.850

0.862

Unknown

375

52 (13.9)

65 (17.3)

7 (1.9)

10 (2.7)

0 (0.0)

6 (1.6)

9 (2.4)

1 (0.3)