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Table 4 The results of specific CTLs of different substances and different effective target ratios in the HPV16, 18 and 58 groups of tumor-bearing mice

From: Construction and immune effect of an HPV16/18/58 trivalent therapeutic adenovirus vector vaccine

Effective target ratio

HPV16

HPV18

HPV58

Vaccine group

AD-NC group

PBS group

Vaccine group

AD-NC group

PBS group

Vaccine group

AD-NC group

PBS group

10:1

11.678%

3.857%

1.867%

14.682%

4.509%

3.031%

15.381%

3.115%

2.501%

20:1

21.201%

4.840%

6.798%

22.871%

4.509%

4.906%

22.807%

2.277%

4.105%

40:1

30.160%*

2.580%

3.136%

30.890%*

4.467%

5.563%

33.050%*

3.102%

6.168%

  1. *After the three groups of tumor-bearing mice were vaccinated, the specific CTL stimulated by the vaccine group was significantly higher than that of the AD-NC or PBS group, and the difference was statistically significant (P < 0.05). There was no significant difference in the average killing rate between the latter two groups with different target ratios