Table 4 Associations between the presence of Mollicutes, H. pylori, F. nucleatum and M. hyorhinis and clinicopathological factors

Gender

Male

54 (74.0)

6 (11.1)

0.781

4 (7.4)

0.670

12 (22.2)

0.142

4 (7.4)

0.102

5 (8.5) ^a

0.446 ^a

Female

19 (26.0)

3 (15.8)

2 (10.5)

4 (21.1)

4 (21.1)

3 (14.3) ^a

Age

 ≤ 59

18 (24.7)

1 (5.6)

0.553

2 (11.1)

0.607

4 (22.2)

0.030

1 (5.6)

0.398

0 (0.0) ^a

0.108 ^a

 > 59

55 (75.3)

8 (14.5)

4 (7.3)

15 (27.3)

7 (12.7)

8 (12.9) a

Tumour size (cm)

 ≤ 4

24 (32.9)

4 (16.7)

0.430

2 (8.3)

0.980

6 (25.0)

0.053

3 (12.5)

0.768

4 (14.8) ^a

0.306 ^a

 > 4

49 (67.1)

5 (10.2)

4 (8.2)

13 (26.5)

5 (10.2)

4 (7.5) ^a

TNM staging

I/II

20 (27.4)

3 (15.0)

0.670

1 (5.0)

0.538

2 (10.0)

4.040

3 (15.0)

0.497

2 (8.7) ^a

0.805 ^a

III/IV

53 (72.6)

6 (11.3)

5 (9.4)

17 (32.1)

5 (9.4)

6 (10.5) ^a

Metastasis

Positive

41 (56.2)

7 (17.1)

0.163

6 (14.6)

0.024

12 (29.3)

0.326

6 (14.6)

0.255

5 (10.9) ^a

0.763 ^a

Negative

32 (43.8)

2 (6.3)

0 (0.0)

7 (21.9)

2 (6.3)

3 (8.8) ^a

Regional lymph nodes

NX

3 (4.1)

0 (0.0)

0.476

0 (0.0)

0.196

0 (0.0)

4.336

0 (0.0)

0.366

2 (50.0) ^a

0.064 ^a

N0

28 (38.4)

2 (7.1)

0 (0.0)

6 (21.4)

2 (7.1)

2 (6.9) ^a

N1

26 (35.6)

3 (11.5)

4 (15.4)

8 (30.8)

2 (7.7)

2 (6.7) ^a

N2

12 (16.4)

3 (25.0)

2 (16.7)

5 (41.7)

3 (25.0)

1 (7.7) ^a

N3

4 (5.5)

1 (25.0)

0 (0.0)

0 (0.0)

1 (25.0)

1 (25.0) ^a

Lymphatic invasion

Positive

43 (58.9)

7 (16.3)

0.219

6 (13.9)

0.033

13 (30.2)

0.736

6 (13.9)

0.327

4 (8.3) ^a

0.543 ^a

Negative

30 (41.1)

2 (6.7)

0 (0.0)

6 (20.0)

2 (6.7)

4 (12.5) ^a

Vascular invasion

Positive

11 (15.1)

2 (18.2)

0.522

2 (18.2)

0.192

6 (54.5)

3.421

1 (9.1)

0.830

2 (14.3) ^a

0.556 ^a

Negative

62 (84.9)

7 (11.3)

4 (6.5)

13 (21.0)

7 (11.3)

6 (9.1) ^a

Tumour type (Lauren's Class.) ³

Intestinal

39 (53.4))

2 (5.1)

0.110

2 (5.1)

0.028

6 (15.4)

2.609

3 (7.7)

0.564

1 (2.6) ^a

0.077 ^a

Diffuse

33 (45.2

7 (21.2)

3 (9.1)

13 (39.4)

5 (15.2)

6 (18.2) ^a

Histopathological grade

GX

1 (1.4)

0 (0.0)

0.109

1 (100.0)

0.008

10 (25.6)

1.331

0 (0.0)

0.649

0 (0.0) ^a

0.892 a

G1

39 (53.4)

2 (5.1)

2 (5.1)

0 (0.0)

3 (7.7)

4 (8.9) ^a

G2

31 (42.5)

6 (19.4)

3 (9.7)

9 (29.0)

5 (16.1)

4 (12.5) ^a

G3

2 (2.7)

1 (50.0)

0 (0.0)

0 (0.0)

0 (0.0)

2 (100.0) ^a

G4

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0) ^a

Haemorrhage

Positive

30 (41.1)

3 (10.0)

0.395

3 (10.0)

0.861

8 (26.7)

0.084

3 (10.0)

0.586

4 (13.3) ^a

0.764 ^a

Negative

43 (58.9)

6 (14.0)

3 (16.3)

11 (25.6)

5 (11.6)

4 (9.3) ^a

Inflammation

Positive

17 (23.3)

3 (17.6)

0.446

3 (17.6)

0.106

5 (29.4)

0.072

2 (11.8)

0.903

2 (8.7) ^a

0.805 ^a

Negative

56 (76.7)

6 (10.7)

3 (5.4)

14 (25.0)

6 (10.7)

6 (10.5) ^a

Presence of eosinophils

Positive

13 (17.8)

3 (23.1)

0.194

2 (15.4)

0.299

4 (30.8)

0.087

2 (15.4)

0.573

1 (6.7) ^a

0.633 ^a

Negative

60 (82.2)

6 (10.0)

4 (6.7)

15 (25.0)

6 (10.0)

7 (10.8) ^a

Presence of neutrophils

Positive

14 (19.2)

2 (14.3)

0.804

2 (14.3)

0.358

2 (14.3)

2.049

1 (7.1)

0.611

1 (5.6) ^a

0.475 ^a

Negative

59 (80.2)

7 (11.9)

4 (6.8)

17 (28.9)

7 (11.9)

7 (11.3) ^a

Presence of macrophages

Positive

17 (23.3)

0 (0.0)

0.078

0 (0.0)

0.159

3 (17.6)

0.872

1 (5.9)

0.444

0 (0.0) ^a

0.096 ^a

Negative

56 (76.7)

9 (16.1)

6 (10.7)

16 (28.6)

7 (12.5)

8 (13.1) ^a

Tissue necrosis

Positive

16 (21.9)

4 (25.0)

0.081

0 (0.0)

0.176

5 (31.3)

0.621

2 (12.5)

0.823

3 (18.8) ^a

0.192 ^a

Negative

57 (78.1)

5 (8.8)

6 (10.5)

14 (24.6)

6 (10.5)

5 (7.8) ^a

Papillary arrangements

Positive

6 (8.2)

3 (50.0)

0.003

0 (0.0)

0.444

0 (0.0)

2.389

1 (16.7)

0.640

2 (28.6) ^a

0.086 a

Negative

67 (91.8)

6 (9.0)

6 (9.0)

19 (28.4)

7 (10.4)

6 (8.2) ^a

Tumour location

Cardia

4 (5.5)

1 (25.0)

0.703

0 (0.0)

0.365

0 (0.0)

1.698

1 (25.0)

0.759

0 (0.0) ^a

0.881 ^a

Body

25 (34.2)

4 (16.0)

4 (16.0)

6 (24.0)

2 (8.0)

3 (12.0) ^a

Antrum

43 (58.9)

4 (9.3)

2 (4.7)

13 (30.2)

5 (11.6)

5 (10.0) ^a

Body and Antrum

1 (1.4)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)