Fig. 1

CircRHOBTB3 expression was downregulated in HCC but was not affected by clinical stages and infections of HBV and HCV. CircRHOBTB3 expression in paired HCC and non-tumor tissues from HCC patients (n = 62) was analyzed by qRT-PCR (A). CircRHOBTB3 expressions at AJCC stage I or II and stage III or IV HCC tissues were compared (B). CircRHOBTB3 expressions were compared in HCC tissues from patients with HCV infection, HBV infection, and non-infection (C). CircRHOBTB3 levels in SNU-448, SNU-387, and normal liver cell line THLE-2 were measured by qRT-PCR (D). CircRHOBTB3 levels were expressed as the average of three technical qRT-PCR replicates in tissue samples from HCC patients (n = 62) or in cell lines. GAPDH was used for normalization. ** p < 0.01