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Table 2 Odds ratios (OR) and 95% confidence intervals (CI) for associations between methylation levels of differentially methylated regions (DMR) regulating genomically imprinted genes and CIN

From: Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia

 

All, N = 419

ORa (95% CI)

Black, N = 168

ORa (95% CI)

White, N = 206

ORa (95% CI)

Regulatory DMR

CIN2+ vs. ≤CIN1

CIN3+ vs. ≤CIN2

CIN2+ vs. ≤CIN1

CIN3+ vs. ≤CIN2

CIN2+ vs. ≤ CIN1

CIN3+ vs. ≤ CIN2

PEG3

1.16 (0.87–1.56)

0.79 (0.48–1.31)

1.31 (0.76–2.25)

1.71 (0.71–4.10)

1.13 (0.73–1.75)

0.70 (0.37–1.32)

PLAGL1/HYMAI

1.01 (0.73–1.38)

0.92 (0.51–1.66)

0.82 (0.44–1.52)

1.15 (0.51–2.58)

0.98 (0.63–1.52)

0.75 (0.35–1.61)

Kv DMR

1.21 (0.80–1.83)

0.91 (0.43–1.89)

1.22 (0.68–2.17)

1.47 (0.67–3.21)

1.58 (0.74–3.35)

0.88 (0.32–2.26)

IGF2/H19

1.15 (0.72–1.82)

0.76 (0.41–1.42)

0.43 (0.17–1.06)

0.43 (0.14–1.31)

1.61 (0.85–3.06)

0.93 (0.44–2.00)

IGF2AS

1.13 (0.93–1.38)

1.16 (0.82–1.65)

1.20 (0.85–1.71)

1.22 (0.73–2.03)

1.12 (0.85–1.48)

1.08 (0.72–1.61)

MESTIT1/MEST

1.08 (0.74–1.58)

0.90 (0.48–1.70)

1.14 (0.59–2.20)

0.36 (0.13–1.98)

0.88 (0.52–1.47)

1.11 (0.51–2.42)

PEG10

1.15 (0.73–1.81)

1.04 (0.48–2.23)

1.25 (0.50–3.13)

1.73 (0.45–6.74)

1.00 (0.54–1.85)

0.82 (0.32–2.08)

MEG3

1.01 (0.79–1.28)

1.38 (0.95–1.99)

0.95 (0.63–1.44)

1.06 (0.60–1.88)

1.13 (0.80–1.62)

1.58 (0.97–2.58)

  1. Abbreviations: CIN Cervical intraepithelial neoplasia, DMR Differentially methylated region, OR Odds ratio
  2. aOR adjusted for age, high risk HPV, race, smoking and parity
  3. In stratified analyses, ORs for other races (Hispanic/Asian/Pacific Islanders/Native Americans) not shown (n = 45)