Emerging role of human polyomaviruses 6 and 7 in human cancers

Table 3 Prevalence of HPyV6 and HPyV7 in primary cutaneous malignancies

Cancer	Specimen types	Samples n	Method	HPyV6 Positive n (%)	HPyV7 Positive n (%)	Reference
MM	FFPE	47	rt-PCR/Seq.	2 (4.3)	2 (4.3)	[25]
AK	FFPE	31	qPCR	1 (3)	ND	[27]
AK	FFPE	92	Seq.	4 (4.3)	NA	[69]
AK	FFPE	2	qPCR	ND	1 (50)	[53]
VK	FFPE	4	qPCR	3 (75)	3 (75)	[53]
BCC	FFPE	18	qPCR	10 (5.5)	ND	[29]
BCC	FFPE	41	qPCR	3 (7)	ND	[27]
BCC	FFPE	50	rt-PCR/Seq.	1 (2)	2 (4)	[25]
BCC	FFPE	109	PCR/Seq./FISH	23 (21.1)	NA	[68]
SCC	FFPE	8	qPCR	1 (12)	ND	[27]
SCC	FFPE	21	qPCR	8 (38)	ND	[29]
SCC	FFPE	52	qPCR	2 (4)	ND	[27]
SCC	FFPE	86	PCR/Seq./FISH	8 (9.3)	NA	[68]
SCC	FFPE	63	rt-PCR/Seq.	2 (3.2)	1 (1.6)	[25]
SCC IN CLL cases who had BMT	FFPE	3	Bead-based multiplex PCR	1 (33.3)	ND	[28]
SCC	FFPE	11	qPCR	4 (36.4)	6 (54.5)	[53]
SCC	FFPE	17 (6 patients)	rt-PCR/IHC	17 (100)	17 (100)	[26]
KA	FFPE	42	qPCR	2 (5)	ND	[27]
KA	FFPE	59	PCR/Seq/FISH	25 (42.3)	NA	[68]
TB	FFPE	45	PCR/Seq	10 (22.2)	NA	[68]
MCC	FFPE	20	qPCR	2 (10)	ND	[29]
MCC	FFPE	28	rt-PCR	1 (3.5)	1 (3.5)	[30]
CTCLs	FFPE	116	rt-PCR	6 (5.20)	1 (0.90)	[70]
CTCLs	FF	71	rt-PCR	13 (18.3)	ND	[24]
CTCLs	FF and FFPE	35	rt-PCR	7 (20)	3 (8.6)	[71]
Total		1072		157/1072 (14.6)	37/681 (5.4)

AK actinic keratosis, BCC basal cell carcinoma, BMT bone marrow transplantation, CLL chronic lymphocytic leukemia, CTCLs cutaneous T-cell lymphomas, FFPE formalin-fixed paraffin-embedded, FISH fluorescence in situ hybridization, IHC immunohistochemistry, FF fresh frozen tissue, KA keratoacanthoma, MCC Merkel cell carcinoma, MM malignant melanoma, NA not applicable, ND not detected, PCR polymerase chain reaction, qPCR quantitative polymerase chain reaction, rt-PCR real-time polymerase chain reaction, SCC squamous cell carcinoma, Seq Sanger sequencing, TB trichoblastoma, VK verrucous keratosis

ISSN: 1750-9378