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Table 2 Prevalence of HPyV6 and HPyV7 in human non-neoplastic diseases

From: Emerging role of human polyomaviruses 6 and 7 in human cancers

Non-neoplastic disease Specimen Samples
n
Method HPyV6 Positive n (%) HPyV7 Positive n (%) Reference
Cutaneous diseases
 Dyskeratosis and parakeratosis FFPE 3 PCR/qPCR/IHC/ Seq. 2 (66.6) 1 (33.3) [50]
 Lichen simplex chronicus FF 13 rt-PCR 1 (7.7) ND [24]
 Pruritic in Cardiac transplant recipient FFPE 1 IHC/PCR NA 1 (100) [51]
 Pruritic Rash (lung transplant) FFPE 2 IHC/PCR/RCA PCR/rt-PCR NA 2 (100) [52]
 Viral warts FFPE 12 qPCR 3 (25) 8 (66.7) [53]
 Angiolymphoid hyperplasia with eosinophilia or Kimura diseasea FF 1 Shotgun metagenomic/FISH 1 (100) NA [54]
 Angiolymphoid hyperplasia with eosinophilia FFPE 5 qPCR/IHC 4 (80) 0 [55]
 Kimura disease FFPE 5 qPCR/IHC 4 (80) 1 (20) [55]
 Kikuchi disease FFPE 38 qPCR 3 (8) 0 [55]
 Dermatopathic lymphadenitis FFPE 28 qPCR 1 (4) 0 [55]
Non-cutaneous diseases
 Thymic hyperplasia FFPE 20 PCR/IHC/FISH NA 8 (40) [31]
 Chronic tonsillitis & tonsillar hypertrophy FF 78 Luminex-assay 6 (7.7) ND [56]
 Chronic tonsillitis & tonsillar hyperplasia FF 40 qPCR 1 (2.5) ND [57]
 Tonsillectomy (due to chronic tonsillitis, peritonsillar abscess, or sleep apnea syndrome) FF and FFPE 108 qPCR 5 (4.6) 1 (0.9) [58]
 Patients with respiratory symptoms NPA 1232 rt-PCR 2 (0.16) 3 (0.24) [59]
 Respiratory tract infections NPA 887 rt-PCR 15 (1.7) ND [60]
 HIV patients with leukoencephalopathies. CSF 14 NGS/PCR 1 (7.1) NA [61]
 Meningoencephalitis CSF 135 qPCR 1 (0.74) 0 [62]
 Immunocompromised patients scheduled to receive transplants NPS, urine, fecal, plasma 32 rt-PCR 3 (9.4) 1 (3.1) [63]
 Acute gallstone cholangitis Bile fluids 91 rt-PCR 5 (5.5) NA [64]
 Patients with gastrointestinal illness Fecal 185 rt-PCR 1 (0.5) 1 (0.5) [59]
  1. aALHE case with Kimura disease clinical syndromes
  2. FF fresh frozen tissue, FFPE formalin-fixed paraffin-embedded, FISH fluorescence in situ hybridization, IHC immunohistochemistry, NA not applicable, ND not detected, NGS next-generation sequencing, NPA nasopharyngeal aspirates, NPS nasopharyngeal swab, PCR polymerase chain reaction, qPCR quantitative polymerase chain reaction, rt-PCR real-time polymerase chain reaction, Seq Sanger sequencing