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Table 2 Prevalence of HPyV6 and HPyV7 in human non-neoplastic diseases

From: Emerging role of human polyomaviruses 6 and 7 in human cancers

Non-neoplastic disease

Specimen

Samples

n

Method

HPyV6 Positive n (%)

HPyV7 Positive n (%)

Reference

Cutaneous diseases

 Dyskeratosis and parakeratosis

FFPE

3

PCR/qPCR/IHC/ Seq.

2 (66.6)

1 (33.3)

[50]

 Lichen simplex chronicus

FF

13

rt-PCR

1 (7.7)

ND

[24]

 Pruritic in Cardiac transplant recipient

FFPE

1

IHC/PCR

NA

1 (100)

[51]

 Pruritic Rash (lung transplant)

FFPE

2

IHC/PCR/RCA PCR/rt-PCR

NA

2 (100)

[52]

 Viral warts

FFPE

12

qPCR

3 (25)

8 (66.7)

[53]

 Angiolymphoid hyperplasia with eosinophilia or Kimura diseasea

FF

1

Shotgun metagenomic/FISH

1 (100)

NA

[54]

 Angiolymphoid hyperplasia with eosinophilia

FFPE

5

qPCR/IHC

4 (80)

0

[55]

 Kimura disease

FFPE

5

qPCR/IHC

4 (80)

1 (20)

[55]

 Kikuchi disease

FFPE

38

qPCR

3 (8)

0

[55]

 Dermatopathic lymphadenitis

FFPE

28

qPCR

1 (4)

0

[55]

Non-cutaneous diseases

 Thymic hyperplasia

FFPE

20

PCR/IHC/FISH

NA

8 (40)

[31]

 Chronic tonsillitis & tonsillar hypertrophy

FF

78

Luminex-assay

6 (7.7)

ND

[56]

 Chronic tonsillitis & tonsillar hyperplasia

FF

40

qPCR

1 (2.5)

ND

[57]

 Tonsillectomy (due to chronic tonsillitis, peritonsillar abscess, or sleep apnea syndrome)

FF and FFPE

108

qPCR

5 (4.6)

1 (0.9)

[58]

 Patients with respiratory symptoms

NPA

1232

rt-PCR

2 (0.16)

3 (0.24)

[59]

 Respiratory tract infections

NPA

887

rt-PCR

15 (1.7)

ND

[60]

 HIV patients with leukoencephalopathies.

CSF

14

NGS/PCR

1 (7.1)

NA

[61]

 Meningoencephalitis

CSF

135

qPCR

1 (0.74)

0

[62]

 Immunocompromised patients scheduled to receive transplants

NPS, urine, fecal, plasma

32

rt-PCR

3 (9.4)

1 (3.1)

[63]

 Acute gallstone cholangitis

Bile fluids

91

rt-PCR

5 (5.5)

NA

[64]

 Patients with gastrointestinal illness

Fecal

185

rt-PCR

1 (0.5)

1 (0.5)

[59]

  1. aALHE case with Kimura disease clinical syndromes
  2. FF fresh frozen tissue, FFPE formalin-fixed paraffin-embedded, FISH fluorescence in situ hybridization, IHC immunohistochemistry, NA not applicable, ND not detected, NGS next-generation sequencing, NPA nasopharyngeal aspirates, NPS nasopharyngeal swab, PCR polymerase chain reaction, qPCR quantitative polymerase chain reaction, rt-PCR real-time polymerase chain reaction, Seq Sanger sequencing