TY - JOUR AU - Bleeker, M. C. AU - Heideman, D. A. AU - Snijders, P. J. AU - Horenblas, S. AU - Dillner, J. AU - Meijer, C. PY - 2009 DA - 2009// TI - Penile cancer: epidemiology,pathogenesis and prevention JO - World J Urol VL - 27 UR - https://doi.org/10.1007/s00345-008-0302-z DO - 10.1007/s00345-008-0302-z ID - Bleeker2009 ER - TY - STD TI - Morrison BF. Risk factors and prevalence of penile cancer. West Indian Med J. 2014 Oct;63(6):559 ± 560. https://doi.org/10.7727/wimj.2015.381. ID - ref2 ER - TY - STD TI - Spiess PE, Dhillon J, Baumgarten AS, Johnstone PA, Giuliano AR. Pathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapies. CA Cancer J Clin. 2016 Jun 17; 66:481 ± 95. https://doi.org/10.3322/caac.21354. ID - ref3 ER - TY - STD TI - Hakenberg OW, Dräger DL, Erbersdobler A, Naumann CM, Jünemann KP, Protzel C. The Diagnosis and Treatment of Penile Cancer. Dtsch Arztebl Int. 2018 Sep 28;115(39):646–652. doi: https://doi.org/10.3238/arztebl.2018.0646. ID - ref4 ER - TY - STD TI - Afonso LA, Cordeiro TI, Carestiato FN, Ornellas AA, Alves G, Cavalcanti SM. High risk human papillomavirus infection of the foreskin in asymptomatic men and patients with phimosis. J Urol. 2016 Jun;195(6):1784 ± 9. https://doi.org/10.1016/j.juro.2015.12.096. ID - ref5 ER - TY - STD TI - Alemany L, Cubilla A, Halec G, Kasamatsu E, Quirós B, Masferrer E, Tous S, Lloveras B, Hernández-Suarez G, Lonsdale R, Tinoco L, Alejo M, Alvarado-Cabrero I, Laco J, Guimerà N, Poblet E, Lombardi LE, Bergeron C, Clavero O, Shin HR, Ferrera A, Felix A, Germar J, Mandys V, Clavel C, Tzardi M, Pons LE, Wain V, Cruz E, Molina C, Mota JD, Jach R, Velasco J, Carrilho C, López-Revilla R, Goodman MT, Quint WG, Castellsagué X, Bravo I, Pawlita M, Muñoz N, Bosch FX, de Sanjosé S. HPV VVAP study group. Role of Human Papillomavirus in Penile Carcinomas Worldwide. Eur Urol. 2016 May;69(5):953–61. doi:https://doi.org/10.1016/j.eururo.2015.12.007. ID - ref6 ER - TY - JOUR AU - Cubilla, A. L. AU - Lloveras, B. AU - Alejo, M. AU - Clavero, O. AU - Chaux, A. AU - Kasamatsu, E. PY - 2010 DA - 2010// TI - The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay JO - Am J Surg Pathol VL - 34 UR - https://doi.org/10.1097/PAS DO - 10.1097/PAS ID - Cubilla2010 ER - TY - JOUR AU - Cubilla, A. L. AU - Lloveras, B. AU - Alejo, M. AU - Clavero, O. AU - Chaux, A. AU - Kasamatsu, E. PY - 2011 DA - 2011// TI - Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases JO - Am j Surg Pathol VL - 35 UR - https://doi.org/10.1097/PAS.0b013e318203cdba DO - 10.1097/PAS.0b013e318203cdba ID - Cubilla2011 ER - TY - JOUR AU - Ferra´ndiz-Pulido, C. AU - Masferrer, E. AU - de Torres, I. AU - Lloveras, B. AU - Hernandez-Losa, J. AU - Mojal, S. PY - 2013 DA - 2013// TI - Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16 INK4a expression, and prognosis JO - J Am Acad Dermatol VL - 68 UR - https://doi.org/10.1016/j.jaad.2012.05.029 DO - 10.1016/j.jaad.2012.05.029 ID - Ferra´ndiz-Pulido2013 ER - TY - STD TI - Steinestel J, Al Ghazal A, Arndt A, Schnoeller TJ, Schrader AJ, Moeller P, Steinestel K. The role of histologic subtype, p16(INK4a) expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma. BMC Cancer. 2015 Apr 3;15:220. doi: https://doi.org/10.1186/s12885-015-1268-z. ID - ref10 ER - TY - STD TI - Lont AP, Kroon BK, Horenblas S, Gallee MP, Berkhof J, Meijer CJ, Snijders PJ. Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival. Int J Cancer. 2006 Sep 1;119(5):1078-81. doi: https://doi.org/10.1002/ijc.21961. PMID: 16570278. ID - ref11 ER - TY - STD TI - Sand FL, Rasmussen CL, Frederiksen MH, Andersen KK, Kjaer SK. Prognostic Significance of HPV and p16 Status in Men Diagnosed with Penile Cancer: A Systematic Review and Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2018 Oct;27(10):1123–32. doi:https://doi.org/10.1158/1055-9965.EPI-18-0322. ID - ref12 ER - TY - STD TI - Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol. 2016 Jul;70(1):93–105. doi:https://doi.org/10.1016/j.eururo.2016.02.029. ID - ref13 ER - TY - BOOK PY - 2017 DA - 2017// TI - Editors). TNM classification of malignant tumours PB - Sons CY - Union for International Cancer Control; Oxford ID - ref14 ER - TY - STD TI - Gu W, Zhang P, Zhang G, Zhou J, Ding X, Wang Q, Wang B, Wei Y, Jin S, Ye D, Zhu Y. Importance of HPV in Chinese Penile Cancer: A Contemporary Multicenter Study. Front Oncol. 2020 Sep 4;10:1521. doi: https://doi.org/10.3389/fonc.2020.01521. ID - ref15 ER - TY - STD TI - Backes DM, Kurman RJ, Pimenta JM, Smith JS. Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control. 2009 May;20(4):449–57. doi:https://doi.org/10.1007/s10552-008-9276-9. ID - ref16 ER - TY - STD TI - Olesen TB, Sand FL, Rasmussen CL, Albieri V, Toft BG, Norrild B, Munk C, Kjær SK. Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol. 2019 Jan;20(1):145–58. doi:https://doi.org/10.1016/S1470-2045(18)30682-X. ID - ref17 ER - TY - STD TI - Takamoto D, Kawahara T, Kasuga J, Sasaki T, Yao M, Yumura Y, Uemura H. The analysis of human papillomavirus DNA in penile cancer tissue by in situ hybridization. Oncol Lett. 2018 May;15(5):8102–8106. doi: https://doi.org/10.3892/ol.2018.8351. ID - ref18 ER - TY - STD TI - Chaux A, Cubilla AL, Haffner MC, Lecksell KL, Sharma R, Burnett AL, Netto GJ. Combining routine morphology, p16(INK4a) immunohistochemistry, and in situ hybridization for the detection of human papillomavirus infection in penile carcinomas: a tissue microarray study using classifier performance analyses. Urol Oncol. 2014 Feb;32(2):171–7. doi:https://doi.org/10.1016/j.urolonc.2012.04.017. ID - ref19 ER - TY - STD TI - Sakamoto J, Shigehara K, Nakashima K, Kawaguchi S, Nakashima T, Shimamura M, Yasuda M, Kato T, Hasegawa T, Kobori Y, Okada H, Deguchi T, Izumi K, Kadono Y, Mizokami A. Etiological role of human papillomavirus infection in the development of penile cancer. Int J Infect Dis. 2019 Jan; 78:148–154. doi: https://doi.org/10.1016/j.ijid.2018.11.003. ID - ref20 ER - TY - STD TI - Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, Dallenbach-Hellweg G, Schmidt D, von Knebel Doeberitz M. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001 Apr 15;92(2):276 – 84. doi: https://doi.org/10.1002/ijc.1174. PMID: 11291057. ID - ref21 ER - TY - STD TI - Ferreux E, Lont AP, Horenblas S, Gallee MP, Raaphorst FM, von Knebel Doeberitz M, Meijer CJ, Snijders PJ. Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus. J Pathol. 2003 Sep;201(1):109–18. doi:https://doi.org/10.1002/path.1394. ID - ref22 ER - TY - STD TI - Fernández-Nestosa MJ, Guimerà N, Sanchez DF, Cañete-Portillo S, Velazquez EF, Jenkins D, Quint W, Cubilla AL. Human Papillomavirus (HPV) Genotypes in Condylomas, Intraepithelial Neoplasia, and Invasive Carcinoma of the Penis Using Laser Capture Microdissection (LCM)-PCR: A Study of 191 Lesions in 43 Patients. Am J Surg Pathol. 2017 Jun;41(6):820–32. doi:https://doi.org/10.1097/PAS.0000000000000821. ID - ref23 ER - TY - STD TI - Martínez-Bailón C, Mantilla-Morales A, Méndez-Matías G, Alvarado-Cabrero I, Maldonado-Rodríguez R, Quintero-Becerra J, Arias-Flores R, Piña-Sánchez P. Human papillomavirus genotypes and P16INK4A expression in squamous penile carcinoma in Mexican patients. BMC Infect Dis. 2019 Dec 19;19(1):1068. doi: https://doi.org/10.1186/s12879-019-4696-6. ID - ref24 ER - TY - STD TI - Zito Marino F, Ronchi A, Stilo M, Cozzolino I, La Mantia E, Colacurci N, Colella G, Franco R. Multiplex HPV RNA in situ hybridization/p16 immunohistochemistry: a novel approach to detect papillomavirus in HPV-related cancers. A novel multiplex ISH/IHC assay to detect HPV. Infect Agent Cancer. 2020 Jul 14;15:46. doi: https://doi.org/10.1186/s13027-020-00310-x. ID - ref25 ER - TY - STD TI - Bishop JA, Ma XJ, Wang H, Luo Y, Illei PB, Begum S, Taube JM, Koch WM, Westra WH. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol. 2012 Dec;36(12):1874–82. doi:https://doi.org/10.1097/PAS.0b013e318265fb2b. ID - ref26 ER - TY - STD TI - Cohen C, Lawson D, Jiang J, Siddiqui MT. Automated in situ hybridization for human papilloma virus. Appl Immunohistochem Mol Morphol. 2014 Sep;22(8):619–22. doi:https://doi.org/10.1097/PAI.0b013e3182a501a2. ID - ref27 ER - TY - STD TI - Bansal A, Singh MP, Rai B. Human papillomavirus-associated cancers: A growing global problem. Int J Appl Basic Med Res. 2016 Apr-Jun;6(2):84–9. doi: https://doi.org/10.4103/2229-516X.179027. ID - ref28 ER - TY - STD TI - Martins VA, Pinho JD, Teixeira Júnior AAL, Nogueira LR, Silva FF, Maulen VE, Khayat AS, Calixto JRR, Costa HA, Ramalho LNZ, Silva GEB. P16INK4a expression in patients with penile cancer. PLoS One. 2018 Oct 12;13(10):e0205350. doi: https://doi.org/10.1371/journal.pone.0205350. ID - ref29 ER - TY - STD TI - Martins VDCA, Cunha IW, Figliuolo G, Rondon HHMF, de Souza PM, Torres Silva FL, Torres Silva GL, de Souza Bastos M, de Castro DB, Santana MF, Ramasawmy R, Levi JE, Torres KL. Presence of HPV with overexpression of p16INK4a protein and EBV infection in penile cancer-A series of cases from Brazil Amazon. PLoS One. 2020 May 6;15(5):e0232474. doi: https://doi.org/10.1371/journal.pone.0232474. ID - ref30 ER - TY - STD TI - Lenhoff A. Five. FDA-approved HPV assays. MLO Med Lab Obs. 2012 Jul;44(7):14, 16, 18. ID - ref31 ER - TY - STD TI - Lewis JS Jr, Ukpo OC, Ma XJ, Flanagan JJ, Luo Y, Thorstad WL, Chernock RD. Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas–a tissue microarray study utilizing E6/E7 mRNA in situ hybridization. Histopathology. 2012 May;60(6):982–91. doi:https://doi.org/10.1111/j.1365-2559.2011.04169.x. ID - ref32 ER - TY - STD TI - Suresh K, Shah PV, Coates S, Alexiev BA, Samant S. In situ hybridization for high risk HPV E6/E7 mRNA in oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 2021 Jan-Feb;42(1):102782. doi: https://doi.org/10.1016/j.amjoto.2020.102782. ID - ref33 ER - TY - STD TI - Eich ML, Del Carmen Rodriguez Pena M, Schwartz L, Granada CP, Rais-Bahrami S, Giannico G, Amador BM, Matoso A, Gordetsky JB. Morphology. p16, HPV, and outcomes in squamous cell carcinoma of the penis: a multi-institutional study. Hum Pathol. 2020 Feb;96:79–86. doi:https://doi.org/10.1016/j.humpath.2019.09.013. ID - ref34 ER - TY - STD TI - Zargar-Shoshtari K, Spiess PE, Berglund AE, Sharma P, Powsang JM, Giuliano A, Magliocco AM, Dhillon J. Clinical Significance of p53 and p16(ink4a) Status in a Contemporary North American Penile Carcinoma Cohort. Clin Genitourin Cancer. 2016 Aug;14(4):346–51. doi: https://doi.org/10.1016/j.clgc.2015.12.019. ID - ref35 ER -