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Table 1 Key Genes Involved in HBV Associated HCC

From: Identification of key genes in hepatitis B associated hepatocellular carcinoma based on WGCNA

Gene Ensembl ID Description Alias Summary
CCNB1 ENSG00000134057.14 cyclin B1 CCNB The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
GINS1 ENSG00000101003.9 GINS complex subunit 1 PSF1 The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts.
PRC1 ENSG00000198901.13 protein regulator of cytokinesis 1 ASE1 This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters mitosis G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.
KIF20A ENSG00000112984.11 kinesin family member 20A MKLP2, RAB6KIFL
NUSAP1 ENSG00000137804.12 nucleolar and spindle associated protein 1 ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization.
NEK2 ENSG00000117650.12
BUB1B ENSG00000156970.12 BUB1 mitotic checkpoint serine/threonine kinase B BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.