Table 1 Key Genes Involved in HBV Associated HCC

CCNB1

ENSG00000134057.14

cyclin B1

CCNB

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.

GINS1

ENSG00000101003.9

GINS complex subunit 1

PSF1

The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts.

PRC1

ENSG00000198901.13

protein regulator of cytokinesis 1

ASE1

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters mitosis G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.

KIF20A

ENSG00000112984.11

kinesin family member 20A

MKLP2, RAB6KIFL

–

NUSAP1

ENSG00000137804.12

nucleolar and spindle associated protein 1

ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization.

NEK2

ENSG00000117650.12

–

–

–

BUB1B

ENSG00000156970.12

BUB1 mitotic checkpoint serine/threonine kinase B

BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.