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Table 2 Overall and type-specific persistence, incidence and clearance hrHPV infections in 298 screen-positive WLWH

From: Type-specific persistence, clearance and incidence of high-risk HPV among screen-positive Rwandan women living with HIV

hrHPV type

Negative

N (%row)

Incidence

N (%row)

Clearance

N (%row)

Persistence

N (%row)

p*

% Persistencea

p‡

Any

43 (14.4)

20 (6.7)

117 (39.3)

118 (39.6)

< 0.01

50.2

n/a

HPV16

198 (66.4)

14 (4.7)

45 (15.1)

41 (13.8)

< 0.01

47.7

0.03

HPV18

262 (87.9)

5 (1.7)

16 (5.4)

15 (5.0)

0.03

48.4

0.18

HPV31

265 (89.0)

5 (1.7)

19 (6.4)

9 (3.0)

< 0.01

32.1

0.69

HPV33

263 (88.3)

5 (1.7)

13 (4.4)

17 (5.7)

0.09

56.7

0.03

HPV35

262 (87.9)

6 (2.0)

19 (6.4)

11 (3.7)

0.01

36.7

1.00

HPV39

277 (93.0)

6 (2.0)

14 (4.7)

1 (0.3)

0.12

6.7

0.01

HPV45

268 (89.9)

5 (1.7)

14 (4.7)

11 (3.7)

0.06

44.0

0.52

HPV51

261 (87.6)

6 (2.0)

27 (8.7)

5 (1.7)

< 0.01

15.6

< 0.01

HPV52

256 (85.9)

12 (4.0)

17 (5.7)

13 (4.4)

0.46

43.3

0.56

HPV56

258 (86.6)

7 (2.4)

25 (8.4)

8 (2.7)

< 0.01

24.2

0.13

HPV58

263 (88.3)

6 (2.0)

15 (5.0)

14 (4.7)

0.08

48.3

0.23

HPV59

282 (94.6)

5 (1.7)

8 (2.7)

3 (1.0)

0.58

27.3

0.75

HPV66

266 (89.3)

4 (1.3)

23 (7.7)

5 (1.7)

< 0.01

17.9

0.04

HPV68

283 (95.0)

6 (2.0)

7 (2.4)

2 (0.7)

1.00

22.2

0.49

All HPV Infectionsb

3664 (87.8)

92 (2.3)

262 (6.3)

155 (3.6)

< 0.01

37.2

n/a

  1. aSummation of infection-level outcomes of all HPV types i.e., each woman can contribute 14 results for each individual high-risk HPV genotype
  2. bAmong women who were hrHPV positive by AmpFire at the screening visit
  3. *Exact version of the McNemar’s chi-square test; All persistence is type-specific and women can contribute to multiple outcomes since they may have multiple infections
  4. ‡vs. persistence for all other types except that type e.g., HPV16 vs. all other (non-HPV16) hrHPV types (exact version of a Pearson chi-square test))