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Table 2 The proportion of HPV E6/E7 mRNA test result and its diagnostic performance of against histology, 2011–18

From: HPV E6/E7 mRNA test for the detection of high grade cervical intraepithelial neoplasia (CIN2+): a systematic review

Author (S)Prevalence of CIN2+, n (%)HPV DNA testHPV E6/E7 mRNA testmRNA test positivity rate, n(%)Performance of E6/E7 mRNA test
Sen%Spe%PPV%NPV%AU-ROC%
Ratnam, 201128.30%Hybrid Capture 2 (HC2)Aptima964 (68%)96.346.240.096.7 
Waldstrom, 201167(16.5)noneAptima271 (67%)92.538.222.996.3 
Fan, 201897 (50.5)HC2Fluorescence in situ hybridization (FISH)no data91.581.682.790.990.9
Han,2018101 (51.3)No dataNo dataNo data85.266.772.98174.95
Binnicker,201481(23.1)HC2APTIMA230 (65.7%)91.44232.194.2 
Broccolo,201379 (25.6)Quantitative real-time PCRPreTect HPV-Proofer115 (37.3)7781.766.988 
Waldstrom, 201248 (55.8)Linear ArrayAptima103 (31.7%)87.57840.897.3 
Li,201785 (26.7)HC2QuantiVirus HPV E6/E7 RNA 3.0;177 (70.2)88.236.433.989.368.5
Benevolo,201149 (10.6)HC2Pretect HPV-Proofer165 (36%)72733992 
Wang, 2019104 (47.3)HPV DNA chip testOptimygene HR-HPV RT-qDx assay,219 (38.9)85.982.578.287.4 
Liu, 201457 (61.9)NoQuantivirus®135 (40.3)71.974.38261.978
Iftner, 201590 (14.9)HC2Aptima464 (4.9%)87.896.121.199.8 
Sorbye, 2011124 (23.8)NoPreTect HPV-Proofer52 (27.1)89.192.577.396.4 
Duvlis, 201529 (47.5)NoNucliSENS-EasyQ® (PreTect Proofer)74 (17.9)93.1506288.9 
Castro, 201372 (43.6)Nested PCRNucliSENS-EasyQ® (PreTect Proofer)96 (58.2)84.18090.988.9 
Pierry, 201245 (18.3)none(HPV OncoTect 899271  
Alaghehbandan, 2013380 (27.9)HC2PreTect HPV-Proofer525 (38.6)76.168.75589.1 
Clad, 2011252 (59.4)HC2Aptima274 (65)91.775   
Varnai, 201827 (81.8)PCR-based typingPreTect HPV-Proofer38 (58)95558186 
Coquillard, 201173 (28.1)HC2Quantivirus®No data848578 
Shen, 201331 (27.9)HC2Quantivirus®200 (73.5)82.415.522.27563.8
Li, 2016103 (55.4)HC2Quantivirus®138 (74.2)91.34768.181.375.9
Liu, 2017153 (40.3)noneQuantivirus®275 (72.4)93.462.140.597.3 
Benevolo, 2011230 (39.2)HC2PreTect HPV-Proofer166 (10.3)83458091 
Liu, 2018155 (90.6)SepaGene kitRT-PCR assay95 (55.6)55509177 
Persson, 201473 (36.9)Linear Array GenotypingAPTIMA162 (74)78.12536.567.4 
Sorbye, 201169 (23.2)NonePreTect HPV-Proofer97 (32.7)94.2866798 
Andersson, 201187 (56.1)NoneReal-time PCRNo data91686791 
Andersson, 201187 (56.1)NonePreTect HPV-ProoferNo data75777081 
Oliveira, 2013295 (53.8)HC2NucliSENS EasyQ® (PreTect Proofer)305 (55.1)79.372.676.775.5