Table 4 Additional human orthologs of fish TTRgrEEN genes, according to OMA ortholog search algorithm, with functions that do not exist in fish
Name of gene (Fish gene / Human gene) | GO domain | Selected GO progressive functions not encountered in fish | ||
|---|---|---|---|---|
Molecular function (Fish gene / Human gene) | Cellular component (Fish gene / Human gene) | Biological process (Fish gene / Human gene) | ([Fish gene] / [Human gene]) | |
Fish atxn1l / Human ATXN1L | 1 / 3 | 1 / 5 | 0 / 10 | [NO] / lung alveolus development |
Fish id2a / Human ID2 | 1 / 3 | 2 / 4 | 8 / 56 | [NO] / epithelial cell differentiation involved in mammary gland alveolus development, mammary gland epithelial cell proliferation, mammary gland alveolus development, ventricular septum development |
Fish ccr11.1 / Human CX3CR1 | 3 / 4 | 2 / 7 | 4 / 17 | [NO] / cerebral cortex cell migration |
HFish cntnap2a /Human CNTNAP2 | 0 / 2 | 2 / 15 | 1 / 8 | [NO] / cerebral cortex development |
Fish mycn / Human MYCN | 2 / 7 | 1 / 3 | 1 / 20 | [NO] / lung development |
Fish neflb / Human NEFL | 1 / 10 | 2 / 10 | 1 / 29 | [NO] / cerebral cortex development |
Fish notch1b /Human NOTCH1 | 3 / 15 | 1 / 20 | 15 / 162 | [NO] / lung development |
Fish reck / Human RECK | 0 / 5 | 0 / 4 | 7 / 8 | [NO] / embryo implantation |
Fish srd5a1 / Human SRD5A1 | 2 / 7 | 2 / 11 | 4 / 40 | [NO] / cerebral cortex development |
Fish wnt7bb / Human WNT7B | 2 / 3 | 3 / 9 | 4 / 42 | [NO] / trachea cartilage morphogenesis, lobar bronchus development, lung epithelium development, lung development, lung morphogenesis, chorio-allantoic fusion, embryonic placenta morphogenesis, mammary gland epithelium development |
Fish pparg / Human PPARG | 7 / 30 | 2 / 8 | 6 / 81 | [NO] / placenta development |