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Table 2 Expression of p16INK4A in CINs and ISCCs

From: HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

Tissues

Degree of immunoreactivity(%)

1+

2+

3+

Normala

36/36 (100.0)

0/36 (0.0)

0/36 (0.0)

0/36 (0.0)

CIN Ib

1/50 (2.0)

31/50 (62.0)

15/50 (30.0)

3/50 (6.0)

CIN IIc

1/52 (1.9)

5/52 (9.6)

27/52 (51.9)

19/52 (36.5)

CIN IIId

0/44 (0)

6/44 (13.6)

25/44 (56.8)

13/44 (29.5)

ISCCse

0/61 (0)

16/61 (26.2)

14/61 (23.0)

31/61 (50.8)

  1. CIN cervical intraepithelial neoplasia, ISCCs invasive squamous cell carcinomas
  2. a-bP < 0.005, a-cP < 0.005, a-dP < 0.005, a-eP < 0.005, b-cP < 0.005, b-dP < 0.005,
  3. b-eP < 0.005, c-dP > 0.05, c-eP > 0.05, d-eP > 0.05;