Fig. 7
From: Host proteome linked to HPV E7-mediated specific gene hypermethylation in cancer pathways
Prediction of putative regulatory transcription factors and STRING database protein network analysis. Heatmap of regulatory transcription factors of hypermethylated gene candidate promoters, the heatmap demonstrated that GABPA, SP1 and ELK1 were putative transcription factors that possibly participated in DNA methylation (a). STRING database protein network analysis mapping were performed for seeking interacting proteins that presumably associate with transcription factors contributing E7-mediated hypermethylation. The STRING network analysis indicated that E7-mediated hypermethylated genes and putative transcription factors were mostly relevant to cell cycle, viral carcinogen and HPV infection (b)