Skip to main content

Table 1 In vitro findings on the role of EGCG in TNBC cells

From: Current shreds of evidence on the anticancer role of EGCG in triple negative breast cancer: an update of the current state of knowledge

Cell lines

Dose of EGCG

Molecular targets

Ref.

Hs578T

10, 100 μM

ROS ↓ (at 10 μM) ROS ↑ (at 100 μM)

[22]

Hs578T

20 μM

CASP1, CASP3, CASP4, PYCARD, BAG3, RIPK2, XIAP↑

IGF1R, MCL1, TNF↓;

[23]

Hs578T

10 μM

VEGF↓

[24]

Hs578T

10 μM plus 40 nmol p53-siRNA

PYCARD, BAD, BAG3, CD40LG, CD40, CD27, TNFRSF1A, TNFSF8, CARD6, LTBR, BAK1↑; IGF1R, MCL1, TNFRSF25, BRAF, FAS, TP53↓;

[25]

MDA-MB-231

25, 50, 75, 100, 200 μM.

Pretreatment with 25 μM LY294002 or 5 μM wortmannin

+ plus 200 μM EGCG added after 24 h

β-catenin, p-AKT, cyclin D1↓

[21]

MDA-MB231

IC50 (μM) of Epigallocatechin 3- Gallate Synthetic Analogues: G28, G37, G56, M1, M2, G75 (−)-

FASN↓ PARP ↑

[26]

MCF-7, MDA-MB- 231, MDA-MD-157, HCC1806

3 μM m SAHA, 5 μM EGCG

miR-221/222, p27, ERα, PTEN,

E-cadherin, N-cadherin,

[27]

  1. Abbreviations: EGCG epigallocatechin-3-gallate, ROS reactive oxygen species, CASP1 caspase 1, CASP3 caspase 3, CASP4 caspase 4, PYCARD apoptosis-associated speck-like protein containing a card, IGF1R insulin-like growth factor-1 receptor, MCL1 induced myeloid leukemia cell differentiation protein, TNF tumor necrosis factor, BAG3 bcl2 associated athanogene 3, RIPK2 receptor-interacting serine/threonine-protein kinase 2, XIAP X-linked inhibitor of apoptosis protein, VEGF vascular endothelial growth factor, BAD BCL2 associated agonist of cell death, TNFRSF1A tumor necrosis factor receptor superfamily member 1A, TNFSF8 tumor necrosis factor ligand superfamily, member 8, CARD6 caspase recruitment domain family member 6, LTBR lymphotoxin beta receptor, BAK1 BCL2 antagonist/killer 1, TNFRSF25 tumor necrosis factor receptor superfamily member 25, BRAF b-raf serine/threonine-protein, FAS fas cell surface death receptor, TP53 tumor protein p-53, p-AKT phospho-AKT, PARP poly(ADP- ribose) polymerase, SAHA suberoylanilide hydroxamic acid, miR-221/222 microRNA 221/222, ERα estrogen receptor alpha, PTEN phosphatase and tensin homolog