Table 4 Relationship between recurrence after 18 month and patient characteristics
Variable | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
OR (95% CI) | p-value | OR (95% CI)a | p-value | |
Age | 0.95 (0.915–0.992) | 0.018 | 0.99 (0.94–1.04) | 0.762 |
Gender | ||||
 Female | Reference |  | Reference |  |
 Male | 1.02 (0.39–2.68) | 0.967 | – | – |
Cigarette smoker | ||||
 Non-smoker | Reference |  | Reference |  |
 Smoker | 1.66 (0.67–4.09) | 0.272 | – | – |
Family history of tumor | ||||
 Negative family history | Reference |  | Reference |  |
 Positive family history | 4.45 (1.90–10.41) | 0.001 | 4.05 (1.61–10.19) | 0.003 |
HPV | ||||
 Negative | Reference |  | Reference |  |
 Positive | 12.34 (3.13–48.57) | < 0.0001 | 6.93 (1.65–29.23) | 0.008 |
Tumor grade | ||||
 Low grade | Reference |  | Reference |  |
 High grade | 2.44 (1.09–5.46) | 0.030 | 0.95 (0.08–10.66) | 0.961 |
Tumor Stage | ||||
 T0 | Reference |  | Reference |  |
 T1 | 1.31 (0.39–4.36) | 0.665 | 1.09 (0.22–5.40) | 0.911 |
 T2 | 1.96 (0.79–4.85) | 0.146 | 0.25 (0.01–9.33) | 0.451 |
 T3-T4 | 6.15 (1.42–26.72) | 0.015 | 1.16 (0.16–8.19) | 0.878 |
Muscle invasion | ||||
 Negative | Reference |  | Reference |  |
 Positive | 2.67 (1.16–6.11) | 0.020 | 4.62 (0.07–0.317.93) | 0.478 |