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Table 4 Relationship between recurrence after 18 month and patient characteristics

From: Association of human papilloma virus (HPV) infection with oncological outcomes in urothelial bladder cancer

Variable Univariate analysis Multivariable analysis
OR (95% CI) p-value OR (95% CI)a p-value
Age 0.95 (0.915–0.992) 0.018 0.99 (0.94–1.04) 0.762
Gender
 Female Reference   Reference  
 Male 1.02 (0.39–2.68) 0.967
Cigarette smoker
 Non-smoker Reference   Reference  
 Smoker 1.66 (0.67–4.09) 0.272
Family history of tumor
 Negative family history Reference   Reference  
 Positive family history 4.45 (1.90–10.41) 0.001 4.05 (1.61–10.19) 0.003
HPV
 Negative Reference   Reference  
 Positive 12.34 (3.13–48.57) < 0.0001 6.93 (1.65–29.23) 0.008
Tumor grade
 Low grade Reference   Reference  
 High grade 2.44 (1.09–5.46) 0.030 0.95 (0.08–10.66) 0.961
Tumor Stage
 T0 Reference   Reference  
 T1 1.31 (0.39–4.36) 0.665 1.09 (0.22–5.40) 0.911
 T2 1.96 (0.79–4.85) 0.146 0.25 (0.01–9.33) 0.451
 T3-T4 6.15 (1.42–26.72) 0.015 1.16 (0.16–8.19) 0.878
Muscle invasion
 Negative Reference   Reference  
 Positive 2.67 (1.16–6.11) 0.020 4.62 (0.07–0.317.93) 0.478
  1. *OR Odds ratio, CI Confidence interval