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Table 2 Results of bivariable and multivariable Cox regression model with unadjusted and adjusted hazard ratio for development of ECA by patient-reported HIV and other sociodemographic variables at follow up after normal cervical cytology at first CCS in Jos, Nigeria (N = 1413 for final multivariable model)

From: HIV and development of epithelial cell abnormalities in women with prior normal cervical cytology in Nigeria

Variable HR (95% CI) p-value aHR (95% CI) P-value
HIV status
 Uninfected 1.0    
 Infected 1.25 (0.65, 2.41) 0.535 1.78 (0.87, 3.65) 0.116
Age at first CCS
  < 35 years 1.0    
  ≥ 35 years 1.98 (1.43, 2.75) 0.001 1.63 (1.11, 2.41) 0.013
Parity
  < 3 1.0    
  ≥ 3 2.0 (1.45, 2.78) 0.001 1.65 (1.14, 2.37) 0.008
Age at first sex
  > 20 years 1.0    
  ≤ 20 years 0.89 (0.69, 1.16) 0.391
Total lifetime sex partners
  < 3 1.0    
  ≥ 3 0.89 (0.67, 1.18) 0.426
History of vaginal infection
 No 1.0    
 Yes 0.70 (0.51, 0.96) 0.025 0.67 (0.48, 0.93) 0.015
Ever diagnosed with STIs
 No 1.0    
 Yes 0.97 (0.63, 1.50) 0.885
History of Smoking
 No 1.0    
 Yes 0.50 (0.07, 3.60) 0.488
Alcohol consumption
 No 1.0    
 Yes 0.51 (0.25, 1.02) 0.059 0.49 (0.22, 1.05) 0.067
  1. Final multivariate Cox regression model included HIV status at first screen, age at first screening, parity, history of vaginal infection and alcohol consumption (N = 1413). Proportional-hazards assumption test based on Schoenfeld residual (global test: X2 = 18.1, df = 5, P = 0.0029)