HIV and development of epithelial cell abnormalities in women with prior normal cervical cytology in Nigeria

Table 2 Results of bivariable and multivariable Cox regression model with unadjusted and adjusted hazard ratio for development of ECA by patient-reported HIV and other sociodemographic variables at follow up after normal cervical cytology at first CCS in Jos, Nigeria (N = 1413 for final multivariable model)

Variable	HR (95% CI)	p-value	aHR (95% CI)	P-value
HIV status
Uninfected	1.0
Infected	1.25 (0.65, 2.41)	0.535	1.78 (0.87, 3.65)	0.116
Age at first CCS
< 35 years	1.0
≥ 35 years	1.98 (1.43, 2.75)	0.001	1.63 (1.11, 2.41)	0.013
Parity
< 3	1.0
≥ 3	2.0 (1.45, 2.78)	0.001	1.65 (1.14, 2.37)	0.008
Age at first sex
> 20 years	1.0
≤ 20 years	0.89 (0.69, 1.16)	0.391	–	–
Total lifetime sex partners
< 3	1.0
≥ 3	0.89 (0.67, 1.18)	0.426	–	–
History of vaginal infection
No	1.0
Yes	0.70 (0.51, 0.96)	0.025	0.67 (0.48, 0.93)	0.015
Ever diagnosed with STIs
No	1.0
Yes	0.97 (0.63, 1.50)	0.885	–	–
History of Smoking
No	1.0
Yes	0.50 (0.07, 3.60)	0.488	–	–
Alcohol consumption
No	1.0
Yes	0.51 (0.25, 1.02)	0.059	0.49 (0.22, 1.05)	0.067

Final multivariate Cox regression model included HIV status at first screen, age at first screening, parity, history of vaginal infection and alcohol consumption (N = 1413). Proportional-hazards assumption test based on Schoenfeld residual (global test: X² = 18.1, df = 5, P = 0.0029)

ISSN: 1750-9378