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Fig. 4 | Infectious Agents and Cancer

Fig. 4

From: Overexpression of programmed cell death ligand 1 in patients with CIN and its correlation with human papillomavirus infection and CIN persistence

Fig. 4

Hematoxylin–Eosin staining in cervical tissue sample (× 200). a, normal cervical tissue. The cervical tissue were mainly composed of stromal tissue (fibrous connective tissue), blood vessels, and non-keratinized stratified squamous epithelium. b, Cervical tissue samples from women with CIN I. The nuclei of the dysplastic cells were enlarged, irregular, and hyperchromatic, and the histopathologic evaluation of these patients demonstrated a slight dysplasia limited to the basal third of the cervical epithelial layer. c and d, Cervical tissue samples from women with CIN II and III. Moderate or severe dysplasia and more abnormal cells were detected in at least two-thirds of the epithelial layer of the cervical samples in CIN II or III patients. There was an increased nuclear-to-cytoplasmic ratio, loss of cell polarization, and mitotic figures present in dysplastic cells of CIN II-III patients. e, epithelium; s, stroma; bv, blood vessels; arrow, mononuclear cells

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